Japonipene C
Japonipene C is a bakkenolide-type sesquiterpene. Japonipene C can be isolated from Petasites japonicus. Japonipene C exhibits neuroprotective activity. Japonipene C can be used for research on Parkinson's disease.
For research use only. We do not sell to patients.
- CAS No.: 1448439-91-5
- Formula: C24H34O6S
- Molecular Weight:450.59
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Protocols
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
Description
In Vitro
Japonipene C (1.5-15 μM; 2 h) provides the strongest neuroprotective effect among the active sesquiterpenes against CoCl2-induced SH-SY5Y cell death[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.
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Cell Line:SH-SY5Y
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Concentration:1.5-15 μM
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Incubation Time:2 h
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Result:Provided the most potent neuroprotective effect against CoCl2-induced cell death among the active sesquiterpenes, with activity at 15 μM being nearly comparable to that of the positive control α-tocopherol.
Chemical Information
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CAS No. 1448439-91-5
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Molecular Weight 450.59
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Formula C24H34O6S
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SMILES
O(C(CC(C)C)=O)[C@H]1[C@@]2(C[C@@]3(C)[C@@]1([C@@H](OC(/C=C\SC)=O)CC[C@@H]3C)[H])C(=C)COC2=O
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Structure Classification
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Protocols
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Human pluripotent stem cell midbrain dopaminergic neuron differentiation
Human pluripotent stem cells are directed toward midbrain dopaminergic neurons by first inducing a neural floor-plate-like progenitor state, then patterning cells with ventralizing SHH signaling and midbrain/WNT-FGF cues, and finally maturing progenitors into neurons expressing dopaminergic markers such as TH, NURR1/NR4A2, PITX3, DAT/SLC6A3, VMAT2/SLC18A2, GIRK2/KCNJ6, FOXA2, LMX1A, and EN1. The main readouts are loss of pluripotency, acquisition of FOXA2+/LMX1A+ midbrain floor-plate progenitors, emergence of βIII-tubulin+/MAP2+ neurons, and production of TH+ dopaminergic neurons with molecular, dopamine-release, and electrophysiological features of midbrain dopaminergic identity.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Japonipene C Related Classifications
HY-N21769 Related Classifications
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