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KIF2A - kinesin family member 2A Gene

Also Known as HK2; KIF2; CDCBM3

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 3796

About KIF2A

Cytogenetic location: 5q12.1 Genomic coordinates (GRCh38): 5:62,306,206-62,391,025 (from NCBI)

This gene has 21 transcripts (splice variants), 290 orthologues, 41 paralogues and is associated with 2 phenotypes. Broad expression in testis (RPKM 17.8), brain (RPKM 16.2) and 24 other tissues.

Summary

The protein encoded by this gene is a plus end-directed motor required for normal mitotic progression. The encoded protein is required for normal spindle activity during Mitosis and is necessary for normal brain development. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2011]

KIF2A Products (4)

mRNA	Protein	Name
NM_001098511.3	NP_001091981.1	kinesin-like protein KIF2A isoform 2
NM_001243952.2	NP_001230881.2	kinesin-like protein KIF2A isoform 3
NM_001243953.2	NP_001230882.1	kinesin-like protein KIF2A isoform 4
NM_004520.5	NP_004511.2	kinesin-like protein KIF2A isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	References	Source
enables microtubule binding	IDA IDA: Inferred from direct assay	26323690	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	18411309	GOA

Biological Process GO Annotation	Evidence	References	Source
involved in microtubule cytoskeleton organization	IGI IGI: Inferred from genetic interaction	26323690	GOA
involved in mitotic spindle assembly	IMP IMP: Inferred from mutant phenotype	15843429	GOA
involved in mitotic spindle organization	IDA IDA: Inferred from direct assay	18411309	GOA
involved in regulation of cell migration	IGI IGI: Inferred from genetic interaction	26323690	GOA

Cellular Component GO Annotation	Evidence	References	Source
part of centriolar subdistal appendage	IDA IDA: Inferred from direct assay	23213374	GOA
located in centriole	IDA IDA: Inferred from direct assay	23213374	GOA
located in centrosome	IDA IDA: Inferred from direct assay	21399614	GOA
located in cytoplasm	IDA IDA: Inferred from direct assay	26323690	GOA
colocalizes with microtubule	IDA IDA: Inferred from direct assay	26323690	GOA
colocalizes with spindle microtubule	IDA IDA: Inferred from direct assay	18411309	GOA
colocalizes with spindle pole	IDA IDA: Inferred from direct assay	18411309	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KIF2A Protein Structure

Kinesin

0
200
400
600
706 a.a.

Protein Preferred Names	Protein Names
kinesin-like protein KIF2A	Kinesin, heavy chain, 2

KIF2A Protein-protein interaction Information

Type	Protein Name	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	References
Intra	KIF2A	O00139	CEP170	Homo sapiens	Q5SW79	Anti Tag CoIP	26496610
Intra	KIF2A	O00139	MRPL53	Homo sapiens	Q96EL3	Y2H Array	25416956
Intra	KIF2A	O00139	LARP1B	Homo sapiens	Q659C4	Y2H Array	25416956
Intra	KIF2A	O00139	FAM13C	Homo sapiens	Q8NE31	Y2H Array	31515488
Intra	KIF2A	O00139	FAM13C	Homo sapiens	Q8NE31	Y2H Array	25416956

Cross: Cross-species interaction Intra: Intraspecies interaction

Related Diseases

Diseases	Alias
Cortical Dysplasia, Complex, With Other Brain Malformations 3	Complex Cortical Dysplasia With Other Brain Malformations 3 CDCBM3 Dysplasia ,Cortical, Complex, With Other Brain Malformations, Type 3
Band Heterotopia	Subcortical Band Heterotopia Double Cortex Syndrome Subcortical Laminar Heterotopia Double Cortex Band Heterotopia Of Brain BH Heco Heterotopic Cortex Familial Band Heterotopia Dc Dc Syndrome Heterotopia, Subcortical Band Sbh Sclh Bhy
Complex Cortical Dysplasia With Other Brain Malformations	Cdcbm Dysplasia, Cortical, Complex, With Other Brain Malformations Dysplasia ,Cortical, Complex, With Other Brain Malformations
Bardet-Biedl Syndrome 8	BBS8 Bardet-Biedl Syndrome, Type 8
Tubulinopathy	Tubulinopathies
Spinal Muscular Atrophy With Lower Extremity Predominant	Spinal Muscular Atrophy With Lower Extremity Predominance Autosomal Dominant Childhood-Onset Proximal Spinal Muscular Atrophy With Contractures Kugelberg-Welander Syndrome, Autosomal Dominant Lower Extremity-Predominant Autosomal Dominant Proximal Spinal Muscular Atrophy With Contractures Sma-Led Spinal Muscular Atrophy, Childhood, Proximal, Autosomal Dominant Spinal Muscular Atrophy, Juvenile, Proximal, Autosomal Dominant Spinal Muscular Atrophy, Lower Extremity, Autosomal Dominant Spinal Muscular Atrophy, Lower Extremity, Dominant
Congenital Fibrosis Of The Extraocular Muscles	Congenital Fibrosis Of Extraocular Muscles Cfeom Feom Congenital External Ophthalmoplegia Congenital Fibrosis Syndrome General Fibrosis Syndrome
Microcephaly	Microencephaly Microcephalus Microcephalic Nanocephaly Congenital Microcephaly Brain Hypoplasia Brain Nondevelopment Cephalic Hypoplasia Undeveloped Cerebrum Undeveloped Brain Micrencephalon Micrencephaly
Primary Microcephaly	True Microcephaly Microcephaly, Primary
Mosaic Variegated Aneuploidy Syndrome	Warburton-Anyane-Yeboa Syndrome Mva Syndrome Mosaic Variegated Aneuplody Microcephaly Syndrome Warburton Anyane Yeboa Syndrome
Primary Autosomal Recessive Microcephaly	Autosomal Recessive Primary Microcephaly Mcph True Microcephaly Microcephalia Vera Microcephaly Vera Microcephaly Primary Hereditary Microcephaly, Primary, Autosomal Recessive Primary Microcephaly
Periventricular Nodular Heterotopia	Periventricular Heterotopia Pvnh Familial Nodular Heterotopia Heterotopia, Periventricular Periventricular Heterotopia, X-Linked
Walker-Warburg Syndrome	Hard Syndrome Walker-Warburg Congenital Muscular Dystrophy Cerebroocular Dysplasia-Muscular Dystrophy Syndrome Cod-Md Syndrome Chemke Syndrome Hydrocephalus, Agyria And Retinal Dysplasia Cerebroocular Dysgenesis Cerebroocular Dysplasia Muscular Dystrophy Syndrome Hard +/- E Syndrome Pagon Syndrome Warburg Syndrome Hydrocephalus, Agyria, And Retinal Dysplasia Mddga Muscular Dystrophy-Dystroglycanopathy , Type A Muscular Dystrophy-Dystroglycanopathy [With Brain And Eye Anomalies], Type A Hydrocephalus-Agyria-Retinal Dysplasia Syndrome Wws Dystrophy, Muscular, Dystroglycanopathy, Type A
Congenital Nervous System Abnormality	Congenital Neurologic Anomaly Congenital Nervous System Disorder

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-173522	KIF2C-IN-1		98.08%	Unkown
HY-177898	DHTP	Inhibitor	99.42%	Unkown
HY-RS07282	KIF2A Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20433	Kif2a Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26942	Kif2a Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Macaca mulatta	KIF2A	VGNC	VGNC:74016
Canis familiaris	KIF2A	VGNC	VGNC:42402
Bos taurus	KIF2A	VGNC	VGNC:30599
Mus musculus	KIF2A	MGD	MGI:108390
Rattus norvegicus	KIF2A	RGD	RGD:70974
Felis catus	KIF2A	VGNC	VGNC:67940
Others	KIF2A	NCBI