CCR9
C-C chemokine receptor type 9 (CCR9, CDw199) is the chemokine receptor that specifies gut tropism in lymphocytes through exclusive recognition of CCL25 (TECK), a chemokine constitutively produced by small intestinal and colonic epithelial cells, with highest expression in the jejunum and ileum. CCR9 is acquired by naive T cells during activation in gut-associated lymphoid tissue under retinoic acid and dendritic cell instruction, and is co-expressed with α4β7 integrin to form a two-address-code system for intestinal homing. The receptor marks gut-homing T cells, IgA-committed plasmablasts, and a subset of innate lymphoid cells; engagement of CCL25 triggers Gαi-dependent integrin activation and transendothelial migration into lamina propria. CCR9+ T cells accumulate in the inflamed gut of Crohn's disease and ulcerative colitis patients, driving the rationale for vercirnon, an orally available CCR9 antagonist developed for Crohn's disease. CCR9 is also exploited by gut-tropic T-cell leukemia cells for infiltration, and CCR9-CCL25 interactions support intestinal tumor growth and metastasis.
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CCR9 Recombinant Proteins (2)
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Inhibitors & Agonists (4)
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Recombinant Protein Expression Service
- Codon Optimization
- Gene Synthesis
- Construction of Expression Vector
- Strain Screening
- Protein Expression
- Purification & QC
- Protein Delivery
- Formula: Human
- Molecular Weight: Sf9 insect cells
The EpCAM/TROP1 protein serves as an important homogeneous interacting molecule that promotes direct contact between intestinal epithelial cells (IEC) and intraepithelial lymphocytes (IEL) in the mucosal epithelium. This feature helps establish an immune barrier against mucosal infections. EpCAM/TROP1 Protein, Human (His-SUMO) is the recombinant human-derived EpCAM/TROP1 protein, expressed by E. coli , with N-6*His, N-SUMO labeled tag.
