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製品番号: HY-160254

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1954U89

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 150057-49-1
分子式: C₁₆H₂₁N₅
分子量:283.37

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

1954U89 構造式

CAS 番号: 150057-49-1

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Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

1954U89 is a potent, lipid-soluble and orally active inhibitor of dihydrofolate reductase (DHFR). 1954U89 exhibits anticancer activity^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
143B	IC₅₀	0.8 nM Compound: 5o	Cytotoxic Activity was evaluated against 143B (TK-) tumor cells Cytotoxic Activity was evaluated against 143B (TK-) tumor cells	[PMID: 8632413]
A549	IC₅₀	0.4 nM Compound: 5o	Cytotoxic activity evaluated against A549 tumor cells Cytotoxic activity evaluated against A549 tumor cells	[PMID: 8632413]
Daoy	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against Daoy tumor cells Cytotoxic activity was evaluated against Daoy tumor cells	[PMID: 8632413]
HCT-8	IC₅₀	0.74 nM Compound: 5o	Activity was evaluated against HCT-8 tumor cells Activity was evaluated against HCT-8 tumor cells	[PMID: 8632413]
NCI-H460	IC₅₀	0.5 nM Compound: 5o	Cytotoxic Activity was evaluated against H460 tumor cells Cytotoxic Activity was evaluated against H460 tumor cells	[PMID: 8632413]
P388	IC₅₀	0.12 nM Compound: 5o	Cytotoxic activity was evaluated against P388D1 tumor cells Cytotoxic activity was evaluated against P388D1 tumor cells	[PMID: 8632413]
U-373MG ATCC	IC₅₀	2.3 nM Compound: 5o	Cytotoxic activity was evaluated against U373MG tumor cells Cytotoxic activity was evaluated against U373MG tumor cells	[PMID: 8632413]
U-87MG ATCC	IC₅₀	2.1 nM Compound: 5o	Cytotoxic activity was evaluated against U87MG tumor cells Cytotoxic activity was evaluated against U87MG tumor cells	[PMID: 8632413]
Vero	IC₅₀	1 nM Compound: 5o	Cytotoxic Activity was evaluated against Vero tumor cells Cytotoxic Activity was evaluated against Vero tumor cells	[PMID: 8632413]

化学情報

CAS 番号 150057-49-1
分子量 283.37
分子式 C₁₆H₂₁N₅
SMILES

CC(N1C(CC)CC)=CC2=C1C=CC3=NC(N)=NC(N)=C23
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Studenberg SD, et al. The pharmacokinetics of 1954U89, 1,3-diamino-7-(1-ethylpropyl)-8-methyl-7H-pyrrolo-(3,2-f)quinazoline, in dogs and rats after intravenous and oral administration. Biopharm Drug Dispos. 1997 Jul;18(5):433-42. [Content Brief]

[2]. Chen J C, et al. QSAR Studies on a Series of 7, 8‐Dialkyl‐1, 3‐diaminopyrrolo‐[3, 2‐f] quinazolines with Anticancer Activity[J]. Chinese Journal of Chemistry, 2006, 24(11): 1531-1537.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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