GPR35
G Protein-Coupled Receptor 35
GPR35 is an orphan G protein-coupled receptor (GPCR) that is highly expressed in the gastrointestinal (GI) tract, predominantly in colon epithelial cells (CEC). Kynurenic acid, a metabolite of L-tryptophan, has been proposed to be the endogenous ligand of GPR3535. Upon kynurenic acid-mediated GPR35 activation, β-arrestin 2 translocates to the cell membrane to mediate GPR35 internalization, resulting in receptor desensitization. Single nucleotide polymorphisms of GPR35 have linked this receptor to inflammatory bowel disease and primary sclerosing cholangitis, suggesting a role in gastrointestinal inflammation. In addition, in conjunction with previous findings that link agonism of GPR35 with significant reduction in nociceptive pain, GPR35 has emerged as a potential effector of regulation of mechanical sensitivity and analgesia of the Ret tyrosine kinase, and as a receptor involved in the transmission of anti-inflammatory effects of aspirin– potentially through affecting leukocyte rolling, adhesion and extravasation.
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GPR35 関連製品 (39)
関連製品 (39)
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Kynurenic acid
(キヌレン酸)
0 Images別名: Kynurenic acid; Quinurenic acid; 4-ヒドロキシキノリン-2-カルボン酸; キヌレニン酸Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
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Zaprinast
(Zaprinast)
0 Images別名: ザプリナスト; M&B 22948Zaprinast (M&B 22948) is a selective inhibitor of cGMP-selective Phosphodiesterase (PDE5). Zaprinast causes a significant increase in cGMP levels in myocytes. Zaprinast is a G protein-coupled receptor 35 (GPR35) agonist which activates rat GPR35 strongly and activates human GPR35 moderately. Zaprinast reduces vessel remodeling through antiproliferative and proapoptotic effects.
- Pamoic acid (パモ酸)
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Kynurenic acid (Standard)
0 Images別名: Quinurenic acid (Standard); Fibrostop 2 (Standard)Kynurenic acid (Standard) is the analytical standard of Kynurenic acid. This product is intended for research and analytical applications. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
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Gentisuric acid
0 ImagesGentisuric Acid is a metabolite of Aspirin (HY-14654). Gentisuric Acid activates GPR35. Gentisuric Acid inhibits HIF-1α and HIF-2α. Gentisuric Acid inhibits Mitomycin C (HY-13316)-induced genotoxicity and twin spots (mitotic recombination), reduces spot frequency without reducing survival, and modulates replication or repair of Mitomycin C-damaged DNA. Gentisuric Acid can be used in research on VHL-deficient renal cell carcinoma and Drosophila melanogaster infection.
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Kynurenic acid-d5
0 Images別名: Quinurenic acid-d5; Fibrostop 2-d5Kynurenic acid-d5 is the deuterium labeled Kynurenic acid. Kynurenic acid, an endogenous tryptophan metabolite, is a broad-spectrum antagonist targeting NMDA, glutamate, α7 nicotinic acetylcholine receptor. Kynurenic acid is also an agonist of GPR35/CXCR8.
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DHICA
0 Images製品番号: HY-W018158CAS 番号: 4790-08-3別名: 5,6-Dihydroxyindole-2-carboxylic acidDHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an eumelanin building block, GPR35 agonist and melanin synthesis intermediate. DHICA activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. DHICA interacts with DNA and interferes with Fpg activity. DHICA promotes the generation of single-strand breaks in plasmid DNA. DHICA increases the activity and expression levels of SOD and Catalase. DHICA is applicable to research related to skin cancer and colon cancer.
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ML 145
0 Images製品番号: HY-107536CAS 番号: 1164500-72-4
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Pamoic acid disodium
(Pamoic acid (disodium))
0 Images別名: パモン酸 二ナトリウム塩
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ML314
0 ImagesML314 is a potent, BBB-penetrant and β-arrestin biased molecule agonist of NTR1 (EC50 = 1.9 μM). ML314 shows good selectivity against NTR2 and GPR35, but does not stimulate Ca2+ mobilization. ML314 can attenuate amphetamine-like hyperlocomotion in dopamine transporter knockout mice. ML314 attenuates methamphetamine-associated hyperlocomotion and potentiates the psychostimulant inhibitory effects of a ghrelin antagonist in wild type mouse model. ML314 also acts as an allosteric enhancer of endogenous neurotensin. ML314 antagonizes G protein signaling. ML314 can be studied in research for methamphetamine abuse conditions.
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3-Methoxycatechol
0 Images3-Methoxycatechol is a catechol derivative with endothelium-dependent vasodilatory and antihypertensive activities. 3-Methoxycatechol activates GPR35, triggering dynamic mass redistribution and β-arrestin translocation. 3-Methoxycatechol inhibits tau self-interaction and scavenges free radicals such as DPPH. 3-Methoxycatechol combined with NaNO2 enhances forestomach proliferative lesions and papilloma formation, reduces glandular stomach lesions, and promotes esophageal lesion development. 3-Methoxycatechol can be used for research related to hypertension and papilloma.
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Bufrolin
0 Images製品番号: HY-106481CAS 番号: 54867-56-0Bufrolin is a Cromoglycate (histamine release inhibitor) analog and a high potency agonist of GPR35. Bufrolin promotes interactions between β-arrestin-2 and either human GPR35a or rat GPR35. Bufrolin also serves as antiallergic mast cell stabilizer and inhibit an anti-inflammatory response inducible by the internalization peptide. Bufrolin acts as an anti-inflammatory agent to be used in research of delivering pharmacol linked with internalization peptide.
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Tyrphostin 25
0 Images別名: AG82; Tyrphostin A 25; Tyrphostin AG 82; RG-50875
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