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ML 145 

Cat. No.: HY-107536 Purity: 98.01%
Handling Instructions

ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM). ML 145 has no significant activity for GPR35 at either rodent ortholog.

For research use only. We do not sell to patients.

ML 145 Chemical Structure

ML 145 Chemical Structure

CAS No. : 1164500-72-4

Size Price Stock Quantity
Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1 mL in DMSO USD 132 In-stock
Estimated Time of Arrival: December 31
5 mg USD 120 In-stock
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10 mg USD 200 In-stock
Estimated Time of Arrival: December 31
25 mg USD 400 In-stock
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50 mg USD 750 In-stock
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100 mg USD 1250 In-stock
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500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

ML 145 is a selective and competitive human GPR35/CXCR8 antagonist with an IC50/EC50 of 20.1 nM. ML 145 has over 1000-fold more selective for GPR35 compared to GPR55 (IC50/EC50=21.7 μM)[1]. ML 145 has no significant activity for GPR35 at either rodent ortholog[2].

IC50 & Target

IC50/EC50: 20.1 nM (GPR35), 21.7 μM (GPR55)[1]

In Vitro

ML 145 (10 μM) also fully blocks internalization of human FLAG-GPR35-eYFP in response to varying concentrations of Zaprinast, Cromolyn disodium, and Pamoate[2].
ML 145 is either without effect (mouse) or displays only a small and apparently noncompetitive inhibitory effect (rat) at the rodent orthologs[2].
ML 145 acts as a competitive antagonist for a number of agonists at human GPR35 and has an IC50 value against EC80 concentrations of various GPR35 agonists in the region of 20 nM[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

482.57

Formula

C₂₄H₂₂N₂O₅S₂

CAS No.

1164500-72-4

SMILES

CC(/C=C(S1)/C(N(CCCC(NC2=CC(O)=C(C(O)=O)C=C2)=O)C1=S)=O)=C\C3=CC=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (103.61 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0722 mL 10.3612 mL 20.7224 mL
5 mM 0.4144 mL 2.0722 mL 4.1445 mL
10 mM 0.2072 mL 1.0361 mL 2.0722 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 5 mg/mL (10.36 mM); Suspended solution; Need ultrasonic

*All of the co-solvents are provided by MCE.
References
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Keywords:

ML 145ML145ML-145OthersGPR35CXCR8GPR55Inhibitorinhibitorinhibit

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ML 145
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