2. GPR35 agonist 1

GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good agentgability.

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GPR35 agonist 1 Chemical Structure

GPR35 agonist 1 Chemical Structure

CAS No. : 2079880-92-3

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1 mg USD 320 In-stock
5 mg USD 800 In-stock
10 mg USD 1280 In-stock
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GPR35 agonist 1 Related Antibodies

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Description

GPR35 agonist 1 (compound 50) is a potent and specific G protein-coupled receptor-35 (GPR35)/CXCR8 agonist with an EC50 of 5.8 nM, displays good agentgability[1].

IC50 & Target

EC50: 5.8 nM (GPR35/CXCR8)[1]
Molecular Weight

354.07

Formula

C10H4BrN5O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1OC2=C([N+]([O-])=O)C(O)=C(Br)C=C2C=C1C3=NN=NN3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (141.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.8243 mL 14.1215 mL 28.2430 mL
5 mM 0.5649 mL 2.8243 mL 5.6486 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.8243 mL 14.1215 mL 28.2430 mL 70.6075 mL
5 mM 0.5649 mL 2.8243 mL 5.6486 mL 14.1215 mL
10 mM 0.2824 mL 1.4122 mL 2.8243 mL 7.0608 mL
15 mM 0.1883 mL 0.9414 mL 1.8829 mL 4.7072 mL
20 mM 0.1412 mL 0.7061 mL 1.4122 mL 3.5304 mL
25 mM 0.1130 mL 0.5649 mL 1.1297 mL 2.8243 mL
30 mM 0.0941 mL 0.4707 mL 0.9414 mL 2.3536 mL
40 mM 0.0706 mL 0.3530 mL 0.7061 mL 1.7652 mL
50 mM 0.0565 mL 0.2824 mL 0.5649 mL 1.4122 mL
60 mM 0.0471 mL 0.2354 mL 0.4707 mL 1.1768 mL
80 mM 0.0353 mL 0.1765 mL 0.3530 mL 0.8826 mL
100 mM 0.0282 mL 0.1412 mL 0.2824 mL 0.7061 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GPR35 agonist 12079880-92-3Inhibitorinhibitorinhibit

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