Aclerastide
Based on 1 Customer Validation
Aclerastide (DSC-127) is an angiotensin receptor agonist. Aclerastide also is a peptide analog of angiotensin II. Aclerastide can be used for the research of tissue regeneration in diabetic ulcers.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.62%
- CAS 番号: 227803-63-6
- 分子式: C42H64N12O11
- 分子量:913.03
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保管条件:
Sealed storage, away from moisture and light.
Powder -80°C, 2 years , -20°C, 1 year* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
Angiotensin Receptor アイソフォーム固有の製品をすべて表示
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生物活性
Aclerastide (topically administered; 100 μL; once a day; for 14 days) elevates levels of reactive oxygen species and of active MMP-9[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:db/db mice[2]
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Dosage:100 μL
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Administration:Topically administered, once a day, for 14 days
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Result:Upregulated reactive oxygen species during inflammation.
Increased the levels of the detrimental active MMP-9 in diabetic wounds.
| NCT Number | Sponsor | Condition | Start Date |
Phase
|
|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 227803-63-6
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性状 Solid
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分子量 913.03
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分子式 C42H64N12O11
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Color White to off-white
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別名
DSC-127; NorLeu3-A(1-7)
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配列
Asp-Arg-{Nle}-Tyr-Ile-His-Pro
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シーケンスの短縮
DR-{Nle}-YIHP
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Sealed storage, away from moisture and light
Powder -80°C 2 years -20°C 1 year * In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)
溶剤 & 溶解度
DMSO : ≥ 100 mg/mL (109.53 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
* "≥" means soluble, but saturation unknown.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (275 KB)
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SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
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取扱説明書 (2659 KB)
参考文献
[1]. Kathleen E Rodgers, et al. Acceleration of healing, reduction of fibrotic scar, and normalization of tissue architecture by an angiotensin analogue, NorLeu3-A(1-7). Plast Reconstr Surg. 2003 Mar;111(3):1195-206. [Content Brief]
[2]. Trung T Nguyen, et al. Expression of active matrix metalloproteinase-9 as a likely contributor to the clinical failure of aclerastide in treatment of diabetic foot ulcers. Eur J Pharmacol. 2018 Sep 5;834:77-83. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 1.0953 mL | 5.4763 mL | 10.9525 mL | 27.3814 mL |
| 5 mM | 0.2191 mL | 1.0953 mL | 2.1905 mL | 5.4763 mL | |
| 10 mM | 0.1095 mL | 0.5476 mL | 1.0953 mL | 2.7381 mL | |
| 15 mM | 0.0730 mL | 0.3651 mL | 0.7302 mL | 1.8254 mL | |
| 20 mM | 0.0548 mL | 0.2738 mL | 0.5476 mL | 1.3691 mL | |
| 25 mM | 0.0438 mL | 0.2191 mL | 0.4381 mL | 1.0953 mL | |
| 30 mM | 0.0365 mL | 0.1825 mL | 0.3651 mL | 0.9127 mL | |
| 40 mM | 0.0274 mL | 0.1369 mL | 0.2738 mL | 0.6845 mL | |
| 50 mM | 0.0219 mL | 0.1095 mL | 0.2191 mL | 0.5476 mL | |
| 60 mM | 0.0183 mL | 0.0913 mL | 0.1825 mL | 0.4564 mL | |
| 80 mM | 0.0137 mL | 0.0685 mL | 0.1369 mL | 0.3423 mL | |
| 100 mM | 0.0110 mL | 0.0548 mL | 0.1095 mL | 0.2738 mL |
Aclerastide 関連分類
HY-P2217 関連分類
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