AJM 290
AJM 290 is a Trx-1 inhibitor. AJM 290 is an inhibitor of the HIF-1α COOH-terminal transactivation domain, and blocks HIF-1 binding to DNA.
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- CAS 番号: 840474-95-5
- 分子式: C20H14FNO4S
- 分子量:383.39
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
0.5 μM
Compound: 8b
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Growth inhibition of human A549 cells after 72 hrs by MTT assay
Growth inhibition of human A549 cells after 72 hrs by MTT assay
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[PMID: 17343370] |
| HCT-116 | IC50 |
0.03 μM
Compound: 8b
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Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
Growth inhibition of human HCT116 cells after 72 hrs by MTT assay
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[PMID: 17343370] |
| MRC5 | EC50 |
0.17 μM
Compound: 13
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Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
Cytotoxicity against human MRC5 cells after 3 days by resazurin-based fluorescence assay
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[PMID: 22264753] |
| Panel NCI-60 (60 carcinoma cell lines) | GI50 |
0.016 μM
Compound: 1h
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Mean in vitro GI50 value against 60 human cancer cell line was determined
Mean in vitro GI50 value against 60 human cancer cell line was determined
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[PMID: 15658878] |
化学情報
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CAS 番号 840474-95-5
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分子量 383.39
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分子式 C20H14FNO4S
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SMILES
O=C1C=CC(C=C1)(C2=CC3=C(N2S(=O)(C4=CC=CC=C4)=O)C=C(F)C=C3)O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AJM 290 関連分類
HY-164259 関連分類
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