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製品番号: HY-149367

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Anticancer agent 136

Anticancer agent 136 (compound 22), a C17-triazole analogue of Geldanamycin (GDM; HY-15230), has an IC₅₀ of 3.38 μM for HDF and a K_d of 3.86 μM for Hsp90. Anticancer agent 136 is an apoptosis-inducing agent.

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CAS 番号: 3049419-74-8
分子式: C₄₀H₅₀N₆O₈
分子量:742.86

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Anticancer agent 136 構造式

CAS 番号: 3049419-74-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
NHDF	IC₅₀	3.38 μM Compound: 22	Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Cytotoxicity against human HDF cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
PC-3	IC₅₀	1.11 μM Compound: 22	Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human PC-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
SK-BR-3	IC₅₀	1.16 μM Compound: 22	Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human SK-BR-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]
SK-OV-3	IC₅₀	1.08 μM Compound: 22	Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay Anticancer activity against human SK-OV-3 cells assessed as cell growth inhibition incubated for 72 hrs by SRB assay	[PMID: 37210951]

化学情報

CAS 番号 3049419-74-8
分子量 742.86
分子式 C₄₀H₅₀N₆O₈
SMILES

O=C1C(NCC2=CN(C/C=C/C3=CC=CC=C3)N=N2)=C4C(C(NC(/C(C)=C/C=C\[C@H](OC)[C@@H](OC(N)=O)/C(C)=C/[C@H](C)[C@@H](O)[C@@H](OC)C[C@H](C)C4)=O)=C1)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Natalia Skrzypczak, et al. Modifications of geldanamycin via CuAAC altering affinity to chaperone protein Hsp90 and cytotoxicity. Eur J Med Chem. 2023 Aug 5;256:115450. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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