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製品番号: HY-121020

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Arcapillin

Arcapillin is a flavonoid that can be isolated from Artemisia capillaris Thunb. Arcapillin induces dose-dependent relaxation of ileum and pulmonary artery smooth muscle, causes slight urinary bladder smooth muscle contraction at highest tested concentrations. Arcapillin binds to the active site of SARS-CoV-2 M_pro via interactions with Gln139, His163, and His164, exhibits antiviral activity against SARS-CoV-2 and MERS-CoV. Arcapillin can be used for the research of gastrointestinal disorders, COVID-19, and Middle East respiratory syndrome (MERS).

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 83162-82-7
分子式: C₁₈H₁₆O₈
分子量:360.31

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Arcapillin 構造式

CAS 番号: 83162-82-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

IC₅₀ & Target

PTP1B^[1]

体外実験

Arcapillin binds to the SARS-CoV-2 main protease (PDB: 7L0D) with a docking score of -6.16 kcal mol⁻¹, indicating favorable interactions with the enzyme's active site^[2].
Arcapillin (72 h) exhibits antiviral activity against SARS-CoV-2 in Vero E6 cells with an IC₅₀ of 190.8 μg mL⁻¹, and has a low cytotoxic profile in the same cell line with a CC₅₀ of 1228 μg mL⁻¹, yielding a selectivity index of 6.40^[2].
Arcapillin (72 h) exhibits potent antiviral activity against MERS-CoV in Vero E6 cells with an IC₅₀ of 16.58 μg mL⁻¹, and has a CC₅₀ of 54.17 μg mL⁻¹ in the same cell line, yielding a selectivity index of 3.26^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 83162-82-7
分子量 360.31
分子式 C₁₈H₁₆O₈
SMILES

O=C1C=C(C2=CC(OC)=C(O)C=C2O)OC3=CC(OC)=C(OC)C(O)=C13
Structure Classification
- Flavonoids
- Flavones
Initial Source
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Abu-Niaaj L, et al. Evaluation of Antispasmodic Effect of Arcapillin on Smooth Muscles of Rats. Pharmacogn J. 2019 July 15;11(4):712-717.

[2]. Badawy AM, et al. Dual SARS-CoV-2 and MERS-CoV inhibitors from Artemisia monosperma: isolation, structure elucidation, molecular modelling studies, and in vitro activities. Org Biomol Chem. 2024 Aug 28;22(34):7006-7016. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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