Asp-02
Asp-02 is an orally active AMPK activator. Asp-02 reduces non-fasting blood glucose levels, improves body weight, and normalizes elevated serum levels of aspartate transaminase (SGOT), alanine transaminase (SGPT), alkaline phosphatase (ALP), urea and creatinine. Asp-02 can be used in the research of type 2 diabetes.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 86711-45-7
- 分子式: C23H20O2
- 分子量:328.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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生物活性
Asp-02 exhibits favourable drug-like ADME properties, including high intestinal permeability (3724.85 nm/s), 100% predicted oral absorption, and limited CNS penetration, indicating good pharmacokinetic potential[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Albino Wistar (8-12 weeks old, 140-180 g, male and female, alloxan-nicotinamide-induced type 2 diabetes)[1]
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Dosage:10 mg/kg
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Administration:p.o.; daily; 25 days
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Result:Reduced non-fasting blood glucose from 559.0 mg/dL on Day 0 to 99.3 mg/dL on Day 25, corresponding to an 82.23% reduction in female rats.
Increased body weight by 15.20% over the 25-day period in female rats.
Reduced non-fasting blood glucose from 517.5 mg/dL on Day 0 to 75.5 mg/dL on Day 25, corresponding to an 85.41% reduction in male rats.
Increased body weight by 36.61% over the 25-day period in male rats.
Normalized serum biochemical parameters to near-control values: reduced SGOT to 205 IU/L, SGPT to 81 IU/L, ALP to 214 IU/L, urea to ~57 mg/dL, and creatinine to ~0.93 mg/dL in female rats; reduced urea to ~51 mg/dL and creatinine to ~0.95 mg/dL, with comparable improvements in hepatic enzyme levels in male rats.
化学情報
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CAS 番号 86711-45-7
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分子量 328.41
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分子式 C23H20O2
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SMILES
O=C(C1=CC=C(C)C=C1)C=CC2=CC=C(C=C2)OCC3=CC=CC=C3
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Asp-02 関連分類
HY-W083125 関連分類
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- Asp-02
- 86711-45-7
- Asp02
- Asp 02
- AMPK
- Aminotransferases (Transaminases)
- Phosphatase
- type 2 diabetes
- human AMPK α2β2 heterotrimers
- alloxan-nicotinamide-induced type 2 diabetic model
- ADME properties
- AMP-activated protein kinase
- Wistar rats
- AMPK α2β2γ1
- AMPK allosteric drug and metabolite site
- Claisen-Schmidt condensation
- human AMPK α2β1 heterotrimers
- Inhibitor
- inhibitor
- inhibit