AZ-008
AZ-008 is a PPI-stabilizing molecular glue that acts as a 14-3-3σ/p53T387 protein-protein interaction stabilizer. AZ-008 has potential for cancer research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2488429-67-8
- 分子式: C15H20N4O2S
- 分子量:320.41
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- プロトコル
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
IC50 & Target
[1]|
14-3-3σ |
体外実験
AZ-008 (2000 µM) binds the same 14-3-3σ pocket in the presence or absence of p53pT387 and increases the amount of 14-3-3σ/p53pT387 complex in solution as shown by TROSY-HSQC NMR[1].
AZ-008 (1 mM; 1 h) increases the binding of 14-3-3σ to the fluorescently labeled p53pT387 peptide in FP, consistent with a weak stabilizing effect[1].
AZ-008 (1 mM) stabilizes the binding of 14-3-3σ to the immobilized p53pT387 peptide in SPR, consistent with a weak stabilizing effect[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 2488429-67-8
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分子量 320.41
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分子式 C15H20N4O2S
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SMILES
CC(OC1=C2C(C=C(C(N)=N)S2)=C(C(NCCN)=O)C=C1)C
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
AZ-008 関連分類
HY-190159 関連分類
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