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United States

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製品番号: HY-124052

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AZ-27

AZ-27 is a respiratory syncytial virus (RSV) inhibitor. AZ-27 can differentially suppress various RSV polymerase activities at the promoter, thereby inhibiting the early stages of mRNA transcription and genome replication by targeting the promoter.

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CAS 番号: 1516772-44-3
分子式: C₃₆H₃₅N₅O₄S
分子量:633.76

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

AZ-27 構造式

CAS 番号: 1516772-44-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
BHK-21	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay Antiviral activity against Respiratory syncytial virus A2 infected in hamster BHK21 cells after 2 days by luciferase reporter gene assay	[PMID: 24211022]
HEp-2	CC₅₀	>50 μM Compound: 11f	Cytotoxicity against human Hep2 cells Cytotoxicity against human Hep2 cells	[PMID: 24211022]
HEp-2	EC₅₀	0.01 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus A2 infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]
HEp-2	EC₅₀	1 μM Compound: 11f	Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA Antiviral activity against Respiratory syncytial virus B-Washington infected in human Hep2 cells after 3 days by ELISA	[PMID: 24211022]

化学情報

CAS 番号 1516772-44-3
分子量 633.76
分子式 C₃₆H₃₅N₅O₄S
SMILES

O=C(C(S1)=CC2=C1C3=CC=CC=C3N(C(C4=CC=C(NC(C5=CC=CN=C5N(CC6)CCC76COC7)=O)C=C4)=O)CC2)NC8CC8
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (270 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Noton SL, et al. Respiratory Syncytial Virus Inhibitor AZ-27 Differentially Inhibits Different Polymerase Activities at the Promoter. J Virol. 2015 Aug;89(15):7786-98. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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