Azaphilone-9
Azaphilone-9 (AZA-9) is an inhibitor of HuR-ARE RNA interaction (IC50=1.2 μM) by binding RNA-binding protein Hu antigen R (HuR). The HuR-RNA interactions stabilize many oncogenic mRNAs in tumors. Thus Azaphilone-9 potentially inhibit cancer cell growth and progression.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1448460-87-4
- 分子式: C21H23BrO5
- 分子量:435.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
HuR-ARE[1]
Azaphilone-9 is a HuR-RNA inhibitor. However HuR binds and stabilizes the AREs of the oncogene Musashi1 (Msi1) and anti-apoptotic proteins, Bcl2 and XIAP, thereby up-regulating their expression and activating the Wnt/Notch signaling pathway and inhibiting apoptosis[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 1448460-87-4
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分子量 435.31
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分子式 C21H23BrO5
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SMILES
O=C1C(C)(OC(C)=O)C(C2=COC(/C=C/C(C)=C/[C@@H](C)CC)=CC2=C1Br)=O
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別名
AZA-9
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Azaphilone-9 関連分類
HY-124844 関連分類
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