Brelovitug
Based on 1 Customer Validation
Brelovitug (BJT-778) is a humanized IgG1 neutralizing monoclonal antibody targeting hepatitis B surface antigen (HBsAg). Brelovitug binds with high affinity to HBsAg purified from HBV serotypes ad and ay, with Kd values of 0.22 nM and 0.39 nM, respectively. Brelovitug binds with high affinity to HBsAg of HBV genotypes A, B, C and D, with IC50 values of 0.07, 0.02, 0.02 and 0.07 nM, respectively. Brelovitug can be used in research related to chronic hepatitis B and chronic hepatitis D.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99%
- CAS 番号: 3033337-14-0
- 分子量:143.954 kDa
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
製品説明
Isotype
Human IgG1 lambda2
Recommend Isotype Controls
Species Reactivity
Virus
IC50 & Target
HbsAg
体外実験
Brelovitug binds to wild-type and clinically mutated HBsAg (D144A, T126S, M133L) with IC50 values ranging from 0.03 to 0.99 nM, but does not bind to HBsAg bearing the G145R mutation[1].
Brelovitug (8 days) potently neutralizes HBV infection in primary human hepatocytes, with EC50 values of 0.09 nM for HBsAg inhibition and 0.11 nM for HBeAg inhibition[1].
Brelovitug (8 days) potently neutralizes HDV infection in HBV/HDV co-infected primary human hepatocytes, with an EC50 value of 0.01 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
体内実験
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Fah/Rag2/IL-2rγ triple knockout (FRG) (humanized, chronic HBV infection model)[1]
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Dosage:20 mg/kg
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Administration:i.p.; dosed on day 0 and day 21
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Result:Rapidly depleted serum HBsAg and maintained HBsAg depletion for up to 14 days post-dosing.
Conjugated
Unconjugated
Reconsititution
The product can be reconstituted/diluted with sterile PBS or saline.
Format
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IgG1-lambda
アプリケーション
ELISA, FACS, Functional assay
化学情報
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CAS 番号 3033337-14-0
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性状 Liquid
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分子量 143.954 kDa
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Color Colorless to light yellow
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SMILES
N/A
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別名
BJT-778
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輸送条件
Shipping with dry ice.
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Formulation
Please refer to the lot-specific COA for specific buffer information.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
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データシート (259 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Inhibitory Antibodies User Guide (603 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Brelovitug 関連分類
HY-P991674 関連分類
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