BVT-116429
BVT-116429 is an 11βHSD1 inhibitor with the activity of increasing adiponectin concentration and improving glucose homeostasis in diabetic mice. BVT-116429 can increase plasma adiponectin levels in diabetic KKAy mice, reduce basal insulin levels, and reduce fasting blood glucose levels after 10 days of inhibition, similar to the effect of rosiglitazone.
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- CAS 番号: 870710-02-4
- 分子式: C13H12F4N2OS
- 分子量:320.31
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
生物活性
製品説明
Cellular Effect
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| CHO | IC50 |
33 nM
Compound: 17
|
Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay
Inhibition of human 11beta-HSD1 over expressed in CHO cells by whole cell assay
|
[PMID: 17266194] |
化学情報
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CAS 番号 870710-02-4
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分子量 320.31
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分子式 C13H12F4N2OS
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SMILES
C[C@@H](C1=C(C=CC=C1)F)NC(S[C@@](C)2C(F)(F)F)=NC2=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
-
保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)