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製品番号: HY-P992094

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Capromab

Capromab is an anti-human PSMA-targeting monoclonal antibody. Capromab binds specifically to the intracellular domain of PSMA, does not undergo internalization after binding, and targets necrotic cells with disrupted membranes. Capromab can be used for the research of prostate cancer.

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 151763-64-3

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Capromab 構造式

CAS 番号: 151763-64-3

容量

価格（税別）

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数量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Isotype

Mouse IgG1 kappa

Recommend Isotype Controls

Mouse IgG1 kappa, Isotype Control

Species Reactivity

Human

体外実験

Capromab (Radiolabeled) (10 nM; 2 h) binds specifically to permeabilized PSMA-expressing LNCaP cells, with minimal unspecific binding to PSMA-negative PC3 cell membranes^[1].
Capromab (¹²⁵I-capromab) (10 nM) retains an immunoreactive fraction of 83 ± 2% when binding to PSMA-expressing LNCaP cell membranes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Capromab (¹²⁵I-capromab) (3 μg per animal; i.v. (tail vein); single dose) demonstrates specific targeting of PSMA-positive prostate cancer xenografts, as shown by significantly lower uptake in PSMA-negative PC3 xenografts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

BALB/c nu/nu mice (male; subcutaneous PC3 xenograft, 3 weeks post-injection)^[1]
Dosage:

3 μg total antibody per animal
Administration:

i.v. (tail vein); single dose
Result:

Showed significantly lower (p < 0.01) tumor uptake in PSMA-negative PC3 xenografts compared to PSMA-positive LNCaP xenografts, with uptake levels comparable to muscle tissue.

遺伝子ID

2346 [NCBI]

アクセッション番号

Q04609

Target

FOLH1/PSMA

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

CAS 番号 151763-64-3
SMILES

[Capromab]
Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Tolmachev V, et al. Development of a 124I-labeled version of the anti-PSMA monoclonal antibody capromab for immunoPET staging of prostate cancer: Aspects of labeling chemistry and biodistribution. Int J Oncol. 2014;44(6):1998-2008. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Amount: USD 0.00

生物活性
- 製品説明
- Isotype
- Recommend Isotype Controls
- Species Reactivity
- 体外実験
- 体内実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
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Capromab

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

Capromab 関連分類

HY-P992094 関連分類