CPD-002
CPD-002 is an inhibitor for vascular endothelial growth factor receptor 2 (VEGFR 2), that inhibits angiogenesis through inhibition of VEGFR2/PI3K/AKT signaling pathway. CPD-002 exhibits anti-inflammatory activity and attenuates rheumatoid arthritis.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2617376-08-4
- 分子式: C17H16N4O2S
- 分子量:340.40
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
VEGFR アイソフォーム固有の製品をすべて表示
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生物活性
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| BaF3 | GI50 |
150 nM
Compound: 6
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Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
Growth inhibition of mouse BaF3 cells harboring TEL-VEGFR2 incubated for 72 hrs by CCK-8 assay
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[PMID: 37216810] |
CPD-002 (0-64 μM, 24-48 h) exhibits cytotoxicity for cells HUVECs and MH7A, in a dose-dependent manner[1].
CPD-002 (0-8 μM, 24 h) inhibits VEGF-induced cell migration and invasion of HUVECs, through suppression of F-actin expression, and chemotactic response to MH7A cell-released chemoattractants[1].
CPD-002 (0-8 μM) exhibits anti-inflammatory activity through inhibition of the inflammatory mediators like TNF-α, IL-1β, IL-6, IL-8, MMP2 and MMP9, and thus inhibits synovial angiogenesis[1].
CPD-002 (0-8 μM, 9 days) inhibits HUVECs tube formation and aortic ring sprout formation in ex vivo rat aortic ring assay[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:HUVECs and MH7A
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Concentration:0-64 μM
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Incubation Time:24-48 h
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Result:Inhibited cell viability in a dose-dependent manner.
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Cell Line:HUVECs
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Concentration:0-8 μM
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Incubation Time:24 h
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Result:Inhibited HUVECs migration in a dose-dependent manner.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:adjuvant-induced arthritis (AIA) Sprague Dawley rats models[1]
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Dosage:15-60 mg/kg
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Administration:i.p., once daily for 14 days
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Result:Ameliorated paw swelling, joint damage, and synovial angiogenesis.
化学情報
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CAS 番号 2617376-08-4
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分子量 340.40
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分子式 C17H16N4O2S
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SMILES
CNC(C1=CC=CC=C1SC2=CC3=C(C(NC(C)=O)=NN3)C=C2)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
CPD-002 関連分類
HY-163533 関連分類
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