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製品番号: HY-P992338

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CT-1119

CT-1119 is an autologous human anti-Mesothelin chimeric antigen receptor macrophage (CAR-M). CT-1119 mediates CAR-dependent, antigen-dependent functional activities. CT-1119 acts as a phagocytosis inducer, tumor cell killer, pro-inflammatory cytokine inducer, and M1 macrophage polarizer. CT-1119 exhibits stronger resistance to M2 repolarization and reduces tumor burden in a mouse lung cancer xenograft model. CT-1119 can be used for the research of mesothelin-expressing solid tumors.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CT-1119 構造式

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Species Reactivity

Human

体外実験

CT-1119 exhibit high CAR expression, high viability, a pro-inflammatory M1 polarization profile, and increased resistance to M2 repolarization^[1].
CT-1119 binds specifically to mesothelin, with binding activity unaffected by mesothelin shedding^[1].
CT-1119 mediates specific, CAR- and antigen-dependent phagocytosis of multiple mesothelin-expressing tumor cell lines^[1].
CT-1119 mediates robust in vitro killing of mesothelin-expressing A549 and MES-OV tumor cell lines^[1].
CT-1119, when stimulated with mesothelin, induces dose-dependent release of pro-inflammatory cytokines including TNFα in both in vitro and cell-based contexts^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

遺伝子ID

10232 [NCBI]

アクセッション番号

Q13421

Target

Mesothelin

Conjugated

Unconjugated

Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.

Format

Product Image

アプリケーション

ELISA, FACS, Functional assay

化学情報

Formulation

Please refer to the lot-specific COA for specific buffer information.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

Inhibitory Antibodies User Guide (603 KB)

参考文献

[1]. Anderson N, et al. 194 Pre-clinical development of CT-1119, a mesothelin targeting chimeric antigen receptor macrophage (CAR-M), for solid tumor immunotherapy[J]. 2022.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

MOQ

Minimum order quantity

100 mg

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Other size

お問い合わせ

Amount: USD 0.00

生物活性
- 製品説明
- Species Reactivity
- 体外実験
- 遺伝子ID
- アクセッション番号
- Target
- Conjugated
- Reconsititution
- Format
- アプリケーション
化学情報
純度とドキュメンテーション
参考文献

製品名:
製品番号:
数量:
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製品名:
CAS 番号:
生物種:
純度:
数量:

CT-1119

PBS Buffer (1×)

DPBS Buffer (1×)

Cytotoxicity LDH Assay Kit

生物活性

化学情報

純度とドキュメンテーション

参考文献

Calculators

Help & FAQs

CT-1119 関連分類

HY-P992338 関連分類