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United States

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製品番号: HY-P10081

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CTP-NBD

CTP-NBD is a cell permeable specific NFκB peptide inhibitor. CTP-NBD could be used in colitis study

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1268513-27-4
分子式: C₁₂₁H₁₉₄N₄₆O₃₂
分子量:2805.12

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

CTP-NBD 構造式

CAS 番号: 1268513-27-4

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

CTP-NBD is a cell permeable specific NFκB peptide inhibitor. CTP-NBD could be used in colitis study^[1]^[2]

NF-κB アイソフォーム固有の製品をすべて表示 :

体外実験

CTP-NBD (200 μM, 6 h) inhibits TNF-α induced luciferase activity in HCT116 cells^[1].
CTP-NBD (200 μM, 6 h) inhibits the expression of IL-8, INOS and COX-2 in RAW264.7 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[1]

Cell Line:

HCT116
Concentration:

200 μM
Incubation Time:

6 h
Result:

Inhibited the luciferase activity induced by TNF-α.

Western Blot Analysis^[1]

Cell Line:

RAW264.7
Concentration:

200 μM
Incubation Time:

6 h
Result:

Inhibited the express of INOS and COX-2 protein.

体内実験

CTP-NBD can not effectively reduce inflammation in colitis rat model, but the modified Colon-targeted CTP-NBD has oral activity and can reduce inflammation in colitis rat model ^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1268513-27-4
分子量 2805.12
分子式 C₁₂₁H₁₉₄N₄₆O₃₂
配列

Tyr-Gly-Arg-Arg-Ala-Arg-Arg-Arg-Ala-Arg-Arg-Thr-Ala-Leu-Asp-Trp-Ser-Trp-Leu-Gln-Thr-Glu
シーケンスの短縮

YGRRARRRARRTALDWSWLQTE
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (261 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Lee Y, et al. Colon-targeted celecoxib ameliorates TNBS-induced rat colitis: a potential pharmacologic mechanism and therapeutic advantages. Eur J Pharmacol. 2014 Mar 5;726:49-56 [Content Brief]

[2]. Hong S, et al. Colon-targeted cell-permeable NFκB inhibitory peptide is orally active against experimental colitis. Mol Pharm. 2012 May 7;9(5):1310-9. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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希釈計算機

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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