Cyjohnphos
Based on 1 Customer Validation
CyJohnPhos (2-(Dicyclohexylphosphino)biphenyl) is an organophosphine ligand. Gold (I) complexes derived from CyJohnPhos exhibit anti-colon cancer activity, inhibit the enzymatic activities of COX-1/COX-2 and TrxR, upregulate ROS levels, induce cell apoptosis, and some derivatives can induce cell cycle arrest. CyJohnPhos can serve as an intermediate for research related to organic synthesis.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度 : 98.0%
- CAS 番号: 247940-06-3
- 分子式: C24H31P
- 分子量:350.49
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保管条件:
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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(Rac)-BINAPIsomer
生物活性
製品説明
体外実験
CyJohnPhos-derived gold (I) complexes exhibit antiproliferative activity against Caco-2/TC7 colon cancer cells. The representative complex [Au (L4)(CyJohnPhos)]SbF6 (4a) has a selectivity index of 7.47. It inhibits COX-1, COX-2 and TrxR, increases intracellular ROS levels in a concentration-dependent manner, induces tumor cell apoptosis, and triggers G1-phase cell cycle arrest[1].
CyJohnPhos (2-(dicyclohexylphosphino) bipheny) (10 mol %) catalyzes the direct arylation of N-substituted indoles, N-substituted pyrroles, and furan substrates with aryl chlorides[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
化学情報
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CAS 番号 247940-06-3
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性状 Solid
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分子量 350.49
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分子式 C24H31P
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Color White to off-white
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SMILES
C1(C2=C(P(C3CCCCC3)C4CCCCC4)C=CC=C2)=CC=CC=C1
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別名
2-(Dicyclohexylphosphino)biphenyl; 2-(ジシクロヘキシルホスフィノ)ビフェニル
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
4°C, protect from light, stored under nitrogen
* In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)
純度とドキュメンテーション
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データシート (283 KB)
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SDS (396 KB)
- English - EN (396 KB)
- Français - FR (396 KB)
- Deutsch - DE (396 KB)
- Norwegian - NO (396 KB)
- Español - ES (396 KB)
- Swedish - SV (396 KB)
- Italian - IT (396 KB)
- Korean - KR (396 KB)
- Portuguese - PT (396 KB)
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取扱説明書 (2659 KB)
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Cyjohnphos 関連分類
HY-W002849 関連分類
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