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製品番号: HY-151919

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FAAH-IN-7

FAAH-IN-7 is a reversible and potent FAAH inhibitor with an IC₅₀ value of 8.29 nM. FAAH-IN-7 suppresses oxidative stress in 1321N1 astrocytes and exhibits notable neuroprotective effect in ex vivo neuroinflammation model.

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CAS 番号: 3037600-36-2
分子式: C₂₆H₂₉N₃O₄
分子量:447.53

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (268 KB)

FAAH-IN-7 構造式

CAS 番号: 3037600-36-2

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生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
Bioz

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
NIH3T3	IC₅₀	6.4 μM Compound: 4e	Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay Cytotoxicity against mouse NIH3T3 cells assessed as inhibition of cell growth measured for 24 hrs by neutral red uptake assay	[PMID: 36462439]

体外実験

FAAH-IN-7 (compound 4e) (10 nM-30 μM; 24 h) has no cytotoxicity against mouse fibroblasts NIH3T3 and human astrocytes cell line 1321N1 with K_i values >10 μM^[1].
FAAH-IN-7 (10 nM, 100 nM; 30 min) inhibits FAAH through a reversible mechanism in the case of rapid dilution. The rapid dilution disrupts the equilibrium between the inhibitor and the enzyme, resulting in enzymatic activity recovery^[1].
FAAH-IN-7 (1 nM-1 μM; 24 h) significantly reduces ROS production starting from the 10 nM concentration in 1321N1 astrocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

1321N1 human astrocytes
Concentration:

10 nM, 100 nM, 1 μM, 10 μM, and 30 μM
Incubation Time:

24 hours
Result:

Showed no cytotoxicity against 1321N1 human astrocytes.

体内実験

FAAH-IN-7 (compound 4e) shows anti-inflammatory effects in inflammation-induced neurodegenerated ex vivo cultures of rat hippocampal explants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 3037600-36-2
分子量 447.53
分子式 C₂₆H₂₉N₃O₄
SMILES

O=C(N1CCN(CCCC2=CC=CC=C2)CC1)OC3=CC=CC(C4=C(C(N)=O)C=C(C)O4)=C3
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (268 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Papa A, et al. Development of potent and selective FAAH inhibitors with improved drug-like properties as potential tools to treat neuroinflammatory conditions. Eur J Med Chem. 2022 Nov 25;246:114952. [Content Brief]

Calculators

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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