Factor B-IN-6
Factor B-IN-6 is an orally active Factor B inhibitor. Factor B-IN-6 exhibits significant inhibitory activity against activation of the human serum serotonin pathway. Factor B-IN-6 can improve the severity of renal lesions and renal function, and reduce urinary protein in animal models. Factor B-IN-6 is useful for kidney disease research.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2797066-55-6
- 分子式: C27H30F2N2O3
- 分子量:468.54
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
Factor B-IN-6 (Compound 4B) has obvious inhibitory activity on the activation of human serum bypass pathway, with an IC50 of 40.7 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Sheep anti-rat Fx1A serum-induced Hyman nephritis rat (7-10 weeks old, weighing 200-300 g) model[1]
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Dosage:5, 20, 60 mg/kg
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Administration:i.g., twice a day, with an interval of 8 hours, 14 days
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Result:Reduced the level of urine egg, and improved renal function.
化学情報
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CAS 番号 2797066-55-6
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分子量 468.54
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分子式 C27H30F2N2O3
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SMILES
CC1=CC(OC)=C(C2=C1NC=C2)CN(CC[C@H](C3CC(F)(F)C3)C4)[C@@H]4C5=CC=C(C(O)=O)C=C5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
Factor B-IN-6 関連分類
HY-177388 関連分類
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