COPS8 - COP9 signalosome subunit 8 Gene

Also Known as COP9; CSN8; SGN8

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10920

About COPS8

Cytogenetic location: 2q37.3 Genomic coordinates (GRCh38): 2:237,085,889-237,100,474 (from NCBI)

This gene has 7 transcripts (splice variants) and 141 orthologues. Ubiquitous expression in brain (RPKM 28.1), testis (RPKM 22.3) and 25 other tissues.

Summary

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S Proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

COPS8 Products (2)

mRNA Protein Name
NM_006710.5 NP_006701.1 COP9 signalosome complex subunit 8 isoform 1
NM_198189.3 NP_937832.1 COP9 signalosome complex subunit 8 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
20399188 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in activation of NF-kappaB-inducing kinase activity IMP
IMP: Inferred from mutant phenotype
22992343 GOA
involved in negative regulation of cell population proliferation IMP
IMP: Inferred from mutant phenotype
23689509 GOA
involved in protein deneddylation IDA
IDA: Inferred from direct assay
19141280 GOA
involved in protein phosphorylation IDA
IDA: Inferred from direct assay
9535219 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
part of COP9 signalosome IDA
IDA: Inferred from direct assay
9535219 GOA
part of COP9 signalosome IPI
IPI: Inferred from physical interaction
25043011 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
24421388 GOA
located in nucleus IDA
IDA: Inferred from direct assay
24421388 GOA
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
9535219 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

COPS8 Protein Structure

CSN8_PSD8_EIF3K

CSN8_PSD8_EIF3K: CSN8/PSMD8/EIF3K family (33 - 165)

  • 0
  • 100
  • 209 a.a.
Protein Preferred Names Protein Names

COP9 signalosome complex subunit 8

  • COP9 constitutive photomorphogenic homolog subunit 8

COPS8 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
COPS8 Q99627 GPS1 Homo sapiens Q13098-7
Pull Down
25043011
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Complementation
32296183
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
TAP
27173435
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Pull Down
25043011
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Y2H Array
32296183
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
MAPPIT
32296183
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
33961781
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Anti Tag CoIP
28514442
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Y2H Prey Pooling
32296183
Intra
COPS8 Q99627 COPS3 Homo sapiens Q9UNS2
Validated Y2H
32296183
Intra
COPS8 Q99627 USHBP1 Homo sapiens Q8N6Y0
Y2H Prey Pooling
25416956
Intra
COPS8 Q99627 USHBP1 Homo sapiens Q8N6Y0
Validated Y2H
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

COPS8 抗体

製品番号 製品名 アプリケーション 反応性
HY-P81934 COPS8 Antibody (YA1679) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat
HY-P81934A COPS8 Antibody (YA1679)(PBS only) WB, IHC-F, IHC-P, ICC/IF, IP Human, Mouse, Rat

関連疾患

Diseases Alias
Xeroderma Pigmentosum, Complementation Group E

  • Xeroderma Pigmentosum V

  • Xp5

  • Xeroderma Pigmentosum, Group E, Ddb-Negative Subtype

  • Xpe

  • Xp, Group E

  • Xeroderma Pigmentosum, Type 5

  • Xeroderma Pigmentosum Complementation Group E

  • XP-E

  • Xp Group E
Smith-Magenis Syndrome

  • SMS

  • Chromosome 17p11.2 Deletion Syndrome

  • 17p11.2 Microdeletion Syndrome

  • 17p11.2 Monosomy

  • Chromosome 17p Deletion Syndrome

  • Del(17)

  • P11.2

  • 17p- Syndrome

  • Deletion 17p Syndrome

  • Partial Monosomy 17p
Dilated Cardiomyopathy

  • Familial Dilated Cardiomyopathy

  • Primary Dilated Cardiomyopathy

  • Idiopathic Dilated Cardiomyopathy

  • Congestive Cardiomyopathy

  • Idiopathic Dilation Cardiomyopathy

  • Primary Familial Dilated Cardiomyopathy

  • Cardiomyopathy, Dilated

  • DCM

  • Cardiomyopathy, Familial Dilated

  • Dilated Cardiomyopathy, Familial

  • Hypokinetic Dilated Cardiomyopathy, Familial

  • Familial Idiopathic Cardiomyopathy

  • Fdc

  • Cardiomyopathy, Familial Idiopathic

  • Idiopathic Cardiomegaly

  • Dilated Congestive Cardiomyopathy

  • Chronic Dilated Cardiomyopathy

  • Ccm - [Congestive Cardiomyopathy]

  • Cocm - [Congestive Cardiomyopathy]

  • Dcm - [Dilated Cardiomyopathy]

  • Dilated-Hypokinetic Cardiomyopathy

  • Congestive Idiopathic Cardiomyopathy

  • Primary Idiopathic Dilated Cardiomyopathy
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03032 COPS8 Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta COPS8 VGNC VGNC:71334
Mus musculus COPS8 MGD MGI:1915363
Felis catus COPS8 VGNC VGNC:61092
Bos taurus COPS8 VGNC VGNC:27606
Rattus norvegicus COPS8 RGD RGD:1311404
Others COPS8 NCBI