SEC61B - SEC61 translocon subunit beta Gene

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 10952

About SEC61B

Cytogenetic location: 9q22.33 Genomic coordinates (GRCh38): 9:99,222,282-99,230,615 (from NCBI)

This gene has 3 transcripts (splice variants) and 208 orthologues. Ubiquitous expression in adrenal (RPKM 68.2), appendix (RPKM 66.5) and 25 other tissues.

Summary

The Sec61 complex is the central component of the protein translocation apparatus of the endoplasmic reticulum (ER) membrane. Oligomers of the Sec61 complex form a transmembrane channel where proteins are translocated across and integrated into the ER membrane. This complex consists of three membrane proteins- alpha, beta, and gamma. This gene encodes the beta-subunit protein. The Sec61 subunits are also observed in the post-ER compartment, suggesting that these proteins can escape the ER and recycle back. There is evidence for multiple polyadenylated sites for this transcript. [provided by RefSeq, Jul 2008]

SEC61B Products (1)

mRNA Protein Name
NM_006808.3 NP_006799.1 protein transport protein Sec61 subunit beta

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence 参考文献 由来
enables epidermal growth factor binding IPI
IPI: Inferred from physical interaction
19602593 GOA
enables protein binding IPI
IPI: Inferred from physical interaction
9792704 GOA
enables ribosome binding IDA
IDA: Inferred from direct assay
32820719 GOA
Biological Process GO Annotation Evidence 参考文献 由来
involved in ERAD pathway IDA
IDA: Inferred from direct assay
8945469 GOA
involved in retrograde protein transport, ER to cytosol IMP
IMP: Inferred from mutant phenotype
17215517 GOA
Cellular Component GO Annotation Evidence 参考文献 由来
located in endoplasmic reticulum IDA
IDA: Inferred from direct assay
18555783 GOA
located in endoplasmic reticulum membrane IDA
IDA: Inferred from direct assay
27044890 GOA
located in endoplasmic reticulum quality control compartment IDA
IDA: Inferred from direct assay
17707796 GOA
located in membrane IDA
IDA: Inferred from direct assay
22375059 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

SEC61B Protein Structure

Sec61_beta

Sec61_beta: Sec61beta family (52 - 91)

  • 0
  • 96 a.a.
Protein Preferred Names Protein Names

protein transport protein Sec61 subunit beta

  • SEC61 translocon beta subunit

SEC61B Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
SEC61B P60468 SEC61A2 Homo sapiens Q9H9S3
Anti Tag CoIP
35271311
Cross
SEC61B P60468 ns7b_sars2 SARS-CoV-2 P0DTD8
Anti Tag CoIP
36217030
Cross
SEC61B P60468 GET3 Saccharomyces cerevisiae Q12154
Crosslink
21866104
Cross
SEC61B P60468 GET3 Saccharomyces cerevisiae Q12154
Pull Down
21866104
Intra
SEC61B P60468 SSR1 Homo sapiens P43307
Anti Bait CoIP
17380188
Intra
SEC61B P60468 SSR1 Homo sapiens P43307
Anti Tag CoIP
35271311
Intra
SEC61B P60468 BCAP31 Homo sapiens P51572
Anti Bait CoIP
18555783
Intra
SEC61B P60468 BCAP31 Homo sapiens P51572
Anti Tag CoIP
18555783
Intra
SEC61B P60468 BCAP31 Homo sapiens P51572
Ub Reconstruction
18555783
Cross: Cross-species interaction Intra: Intraspecies interaction

関連疾患

Diseases Alias
Polycystic Liver Disease

  • Autosomal Dominant Polycystic Liver Disease

  • Isolated Polycystic Liver Disease

  • Pcld

  • Congenital Cystic Liver Disease

  • Congenital Hepatic Cyst

  • Fibrocystic Liver Disease

  • Isolated Autosomal Dominant Polycystic Liver Disease

  • Adpcld

  • Liver Disease, Polycystic

  • Multiple Cysts Of Liver

  • Pld - [Polycystic Liver Disease]

  • Polycystic Liver Disorder

  • Polycystic Liver

  • Congenital Polycystic Disease Of Liver

  • Congenital Polycystic Liver Disease
Liver Disease

  • Liver Failure

  • Liver Diseases

  • Abnormality Of The Liver

  • Liver Dysfunction

  • Disorder Of Liver

  • Hepatic Disorder

  • Hepatic Disease

  • Disease Of Bilirubin Metabolism

  • Disorder Of Bilirubin Metabolism

  • Liver Decompensation

  • Liver Function Failure

  • Hepatic Failure Nos

  • Liver Failure Nos

  • End Stage Liver Disease

  • Decompensated Liver Failure

  • Decompensation Of Liver Function

  • Hepatic Decompensation

  • Hepatic Insufficiency

  • Liver Cell Necrosis With Hepatic Failure

  • Liver Insufficiency

  • Decompensated Liver Disease

  • End Stage Liver Failure

  • Liver Necrosis With Hepatic Failure
Polycystic Kidney Disease 4 With Or Without Polycystic Liver Disease

  • Autosomal Recessive Polycystic Kidney Disease

  • Arpkd

  • Polycystic Kidney Disease, Autosomal Recessive

  • Polycystic Kidney And Hepatic Disease 1

  • Pkhd1

  • PKD4

  • Polycystic Kidney Disease 4 With Or Without Hepatic Disease

  • Polycystic Kidney Disease, Infantile, Type I

  • Polycystic Kidney Disease, Infantile Type

  • Polycystic Kidney, Autosomal Recessive

  • Pkd3, Formerly

  • Polycystic Kidney Disease 4, With Or Without Hepatic Disease

  • Arpkd/Chf

  • Ar-Pkd

  • Polycystic Kidney Disease 4, With Or Without Polycystic Liver Disease

  • Infantile Polycystic Kidney Disease Type I

  • Pkd3

  • Kidney, Polycystic, Disease, Type 4, With/Without Hepatic Disease

  • Polycystic Kidney Disease 3, Autosomal Dominant
Autosomal Dominant Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult Type

  • Adpkd

  • Polycystic Kidney Diseases

  • Polycystic Kidney, Autosomal Dominant

  • Congenital Biliary Ectasias

  • Polycystic Kidney And Hepatic Disease 1

  • Polycystic Kidney Disease, Autosomal Dominant

  • Kidney, Polycystic, Disease, Autosomal Dominant

  • Adult Polycystic Kidney Disease

  • Polycystic Kidney, Adult Type

  • Apckd - [Autosomal Polycystic Kidney Disease]
Polycystic Kidney Disease 1 With Or Without Polycystic Liver Disease

  • Polycystic Kidney Disease 1

  • PKD1

  • Adpkd

  • Polycystic Kidney Disease, Adult, Type I

  • Apkd1

  • Potter Type Iii Polycystic Kidney Disease

  • Polycystic Kidney Disease, Adult

  • Potter Type Iii Polycystic Kidney Disease, Formerly

  • Polycystic Kidney Disease, Type 1

  • Adpkd1

  • Adult Polycystic Kidney Disease Type 1

  • Autosomal Dominant Polycystic Kidney Disease 1

  • Pkd-1

  • Polycystic Kidney Disease Adult

  • Polycystic Kidney Disease Type I

  • Polycystic Kidneys

  • Polycystic Kidney Disease, Adult Type I

  • Polycystic Kidney Type 1 Autosomal Dominant Disease

  • Kidney Disease, Polycystic, Type 1

  • Polycystic Kidney, Autosomal Dominant

  • Polycystic Kidney, Type 1 Autosomal Dominant Disease

  • Polycystic Kidney Diseases
Cystic Kidney Disease

  • Renal Cyst

  • Simple Renal Cyst

  • Kidney Cysts

  • Kidney Diseases, Cystic

  • Renal Cysts

  • Kidney Cyst

  • Cystic Kidney

  • Congenital Cystic Kidney Disease

  • Cystic Kidney Diseases

  • Bosniak 1 Cyst
Polycystic Kidney Disease

  • Polycystic Kidney Diseases

  • Pkd

  • Polycystic Renal Disease

  • Kidney Disease, Polycystic

  • Polycystic Kidney, Autosomal Dominant
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (1)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS12622 SEC61B Human Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus SEC61B MGD MGI:1913462
Bos taurus SEC61B VGNC VGNC:49570
Rattus norvegicus SEC61B RGD RGD:1304997
Felis catus SEC61B VGNC VGNC:64974
Canis familiaris SEC61B VGNC VGNC:49616