HMGCS1 - 3-hydroxy-3-methylglutaryl-CoA synthase 1 Gene

Also Known as HMGCS

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3157

About HMGCS1

Cytogenetic location: 5p12 Genomic coordinates (GRCh38): 5:43,287,470-43,313,412 (from NCBI)

This gene has 7 transcripts (splice variants), 205 orthologues and 1 paralogue. Ubiquitous expression in brain (RPKM 48.5), liver (RPKM 37.3) and 23 other tissues.

Summary

Enables protein homodimerization activity. Predicted to be involved in acetyl-CoA metabolic process and farnesyl diphosphate biosynthetic process, mevalonate pathway. Predicted to be located in cytoplasm. Predicted to be active in cytosol. [provided by Alliance of Genome Resources, Apr 2022]

HMGCS1 Products (9)

mRNA Protein Name
NM_001098272.3 NP_001091742.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324219.2 NP_001311148.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324220.2 NP_001311149.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001324222.2 NP_001311151.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324223.2 NP_001311152.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001324224.2 NP_001311153.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 2
NM_001330663.2 NP_001317592.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_001364188.2 NP_001351117.1 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1
NM_002130.8 NP_002121.4 hydroxymethylglutaryl-CoA synthase, cytoplasmic isoform 1

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
28514442 GOA
enables protein homodimerization activity IDA
IDA: Inferred from direct assay
20346956 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

HMGCS1 Protein Structure

HMG_CoA_synt_N

HMG_CoA_synt_N: Hydroxymethylglutaryl-coenzyme A synthase N terminal (13 - 186)

HMG_CoA_synt_C

HMG_CoA_synt_C: Hydroxymethylglutaryl-coenzyme A synthase C terminal (187 - 469)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 520 a.a.
Protein Preferred Names Protein Names

hydroxymethylglutaryl-CoA synthase, cytoplasmic

  • 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) synthase

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (6)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-179526 Sino-C / Unkown
HY-183967 CNP7 / Unkown
HY-RS06241 HMGCS1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18093 Hmgcs1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24568 Hmgcs1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24905 Hmgcs2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Felis catus HMGCS1 VGNC VGNC:67597
Canis familiaris HMGCS1 VGNC VGNC:103681
Bos taurus HMGCS1 VGNC VGNC:29880
Rattus norvegicus HMGCS1 RGD RGD:70970
Macaca mulatta HMGCS1 VGNC VGNC:73485
Mus musculus HMGCS1 MGD MGI:107592
Others HMGCS1 NCBI