KLC1 - kinesin light chain 1 Gene

Also Known as KLC; KNS2; KNS2A

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 3831

About KLC1

Cytogenetic location: 14q32.33 Genomic coordinates (GRCh38): 14:103,629,211-103,701,544 (from NCBI)

This gene has 27 transcripts (splice variants), 215 orthologues and 5 paralogues. Broad expression in brain (RPKM 108.4), heart (RPKM 21.0) and 23 other tissues.

Summary

Conventional Kinesin is a tetrameric molecule composed of two heavy chains and two light chains, and transports various cargos along microtubules toward their plus ends. The heavy chains provide the motor activity, while the light chains bind to various cargos. This gene encodes a member of the Kinesin light chain family. It associates with Kinesin heavy chain through an N-terminal domain, and six tetratricopeptide repeat (TPR) motifs are thought to be involved in binding of cargos such as vesicles, mitochondria, and the Golgi complex. Thus, Kinesin light chains function as adapter molecules and not motors per se. Although previously named "kinesin 2", this gene is not a member of the kinesin-2 / Kinesin heavy chain subfamily of Kinesin motor proteins. Extensive alternative splicing produces isoforms with different C-termini that are proposed to bind to different cargos; however, the full-length nature and/or biological validity of most of these variants have not been determined. [provided by RefSeq, Jul 2008]

KLC1 Products (32)

mRNA Protein Name
NM_001130107.2 NP_001123579.1 kinesin light chain 1 isoform 3
NM_001394832.1 NP_001381761.1 kinesin light chain 1 isoform 4
NM_001394833.1 NP_001381762.1 kinesin light chain 1 isoform 5
NM_001394834.1 NP_001381763.1 kinesin light chain 1 isoform 6
NM_001394835.1 NP_001381764.1 kinesin light chain 1 isoform 7
NM_001394836.1 NP_001381765.1 kinesin light chain 1 isoform 8
NM_001394837.1 NP_001381766.1 kinesin light chain 1 isoform 9
NM_001394838.1 NP_001381767.1 kinesin light chain 1 isoform 10
NM_001394839.1 NP_001381768.1 kinesin light chain 1 isoform 11
NM_001394840.1 NP_001381769.1 kinesin light chain 1 isoform 12
NM_001394841.1 NP_001381770.1 kinesin light chain 1 isoform 13
NM_001394842.1 NP_001381771.1 kinesin light chain 1 isoform 14
NM_001394843.1 NP_001381772.1 kinesin light chain 1 isoform 15
NM_001394844.1 NP_001381773.1 kinesin light chain 1 isoform 16
NM_001394845.1 NP_001381774.1 kinesin light chain 1 isoform 17
NM_001394846.1 NP_001381775.1 kinesin light chain 1 isoform 18
NM_001394847.1 NP_001381776.1 kinesin light chain 1 isoform 19
NM_001394848.1 NP_001381777.1 kinesin light chain 1 isoform 20
NM_001394849.1 NP_001381778.1 kinesin light chain 1 isoform 21
NM_001394850.1 NP_001381779.1 kinesin light chain 1 isoform 22
NM_001394851.1 NP_001381780.1 kinesin light chain 1 isoform 23
NM_001394852.1 NP_001381781.1 kinesin light chain 1 isoform 24
NM_001394853.1 NP_001381782.1 kinesin light chain 1 isoform 25
NM_001394854.1 NP_001381783.1 kinesin light chain 1 isoform 26
NM_001394855.1 NP_001381784.1 kinesin light chain 1 isoform 27
NM_001394856.1 NP_001381785.1 kinesin light chain 1 isoform 28
NM_001394857.1 NP_001381786.1 kinesin light chain 1 isoform 29
NM_001394858.1 NP_001381787.1 kinesin light chain 1 isoform 30
NM_001394859.1 NP_001381788.1 kinesin light chain 1 isoform 31
NM_001394860.1 NP_001381789.1 kinesin light chain 1 isoform 32
NM_005552.5 NP_005543.2 kinesin light chain 1 isoform 1
NM_182923.4 NP_891553.2 kinesin light chain 1 isoform 2

Gene Ontology

  • Molecular Function
Molecular Function GO Annotation Evidence 参考文献 由来
enables protein binding IPI
IPI: Inferred from physical interaction
14970196 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

KLC1 Protein Structure

Rab5-bind

Rab5-bind: Rabaptin-like protein (80 - 254)

TPR_2

TPR_2: Tetratricopeptide repeat (258 - 285)

TPR_12

TPR_12: Tetratricopeptide repeat (293 - 370)

TPR_1

TPR_1: Tetratricopeptide repeat (381 - 410)

TPR_10

TPR_10: Tetratricopeptide repeat (465 - 495)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 573 a.a.
Protein Preferred Names Protein Names

kinesin light chain 1

  • kinesin 2 60/70kDa

KLC1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
KLC1 Q07866 BNIP2 Homo sapiens Q12982
Validated Y2H
25416956
Intra
KLC1 Q07866 KRT31 Homo sapiens Q15323
Y2H Prey Pooling
25416956
Cross: Cross-species interaction Intra: Intraspecies interaction

KLC1 抗体

製品番号 製品名 アプリケーション 反応性
HY-P82618 KLC1 Antibody (YA2363) WB, IHC-P, ICC/IF, FC, IP Human, Mouse, Rat

関連疾患

Diseases Alias
Melanoma, Cutaneous Malignant 6

  • Melanoma, Cutaneous Malignant, Susceptibility To, 6

  • CMM6

  • Melanoma, Cutaneous Malignant, 6

  • Cutaneous Malignant Melanoma 6

  • Melanoma, Cutaneous, Malignant, Susceptibility To, Type 6
Lung Combined Large Cell Neuroendocrine Carcinoma

  • Combined Large Cell Neuroendocrine Carcinoma Of Lung

  • Pulmonary Combined Large Cell Neuroendocrine Carcinoma

  • Combined Large Cell Lung Neuroendocrine Carcinoma
Occipital Lobe Neoplasm

  • Neoplasm Of Occipital Lobe

  • Malignant Neoplasm Of Occipital Lobe

  • Tumor Of Occipital Lobe
Cataract 28

  • CTRCT28

  • Cataract, Age-Related Cortical, 1

  • Arcc1

  • Cataract 28, Age-Related Cortical, Susceptibility To

  • Cataract 28, Age-Related Cortical

  • Age-Related Cortical Cataract 1
Medulloblastoma

  • MDB

  • Cpnet

  • Localized Primitive Neuroectodermal Tumor

  • Classic Medulloblastoma

  • Medulloblastoma Predisposition Syndrome

  • Medulloblastoma, Somatic

  • Brain Medulloblastoma

  • Cns Pnet

  • Infratentorial Primitive Neuroectodermal Tumor

  • Neuroectodermal Tumors, Primitive

  • Medulloblastomas

  • Desmoplastic Medulloblastoma

  • Medulloblastoma, With Extensive Nodularity

  • Medulloblastoma Of Unspecified Site

  • Medullomyoblastoma Of Unspecified Site
Breast Cancer

  • Breast Carcinoma

  • Male Breast Cancer

  • Breast Cancer, Familial

  • Malignant Neoplasm Of Breast

  • Breast Cancer, Susceptibility To

  • Breast Cancer, Early-Onset

  • Malignant Tumor Of Breast

  • Carcinoma Of Male Breast

  • Breast Cancer, Invasive Ductal

  • Breast Cancer, Protection Against

  • Breast Cancer, Somatic

  • Breast Cancer, Male

  • Breast Cancer, Lobular, Somatic

  • Breast Tumor

  • Mammary Cancer

  • Mammary Tumor

  • Malignant Neoplasm Of Male Breast

  • Mammary Carcinoma

  • Male Breast Carcinoma

  • Familial Cancer Of Breast

  • Invasive Ductal Breast Carcinoma

  • Breast Cancer Susceptibility

  • Breast Cancer, Male, Susceptibility To

  • Breast Cancer, Early-Onset, Susceptibility To

  • Malignant Tumor Of The Breast

  • Mammary Neoplasm

  • Primary Breast Cancer

  • Neoplasm Of Male Breast

  • Carcinoma Of Breast

  • Breast Cancer In Men

  • Familial Breast Cancer

  • Cancer Of Breast

  • BC

  • Breast Cancer Familial

  • Breast Cancer Familial Male

  • Breast Cancer, Familial Male

  • Breast Male Carcinoma

  • Breast Neoplasms

  • Breast Neoplasms, Male

  • Mammary Tumors

  • Mammary Carcinomas

  • Cancer, Breast

  • Cancer, Breast, Susceptibility

  • Invasive Breast Ductal Carcinoma

  • Breast Neoplasm

  • Susceptibility To Breast Cancer

  • Mammary Neoplasms

  • Animal Mammary Neoplasms

  • Primary Malignant Neoplasm Of Breast

  • Infiltrating Ductal Carcinoma Of Breast

  • Infiltrating Duct Carcinoma Of Unspecified Site

  • Infiltrating Ductular Carcinoma Of Unspecified Site

  • Invasive Breast Carcinoma Of No Special Type

  • Microinvasive Carcinoma Of Breast

  • Carcinoma With Apocrine Differentiation
Inflammatory Myofibroblastic Tumor

  • Inflammatory Fibrosarcoma
Dystonia

  • Dystonic Disease

  • Dystonic Disorder

  • Dystonia Disorders

  • Neuroleptic Dyskinesia
Bardet-Biedl Syndrome

  • Bbs

  • Biedl-Bardet Syndrome
Hereditary Spastic Paraplegia

  • Familial Spastic Paraplegia

  • Hereditary Spastic Paraparesis

  • Strumpell-Lorrain Disease

  • Familial Spastic Paraparesis

  • Hsp

  • Spg

  • Strümpell-Lorrain Disease

  • Spastic Paraplegia, Hereditary

  • French Settlement Disease

  • Strumpell-Lorrain Syndrome

  • Fsp

  • Spastic Paraplegia, Familial

  • Spastic Paraplegia Hereditary

  • Spastic Paraplegia 3, Autosomal Dominant

  • Spastic Paraparesis

  • Hereditary Spastic Paralysis

  • Familial Spastic Paralysis

  • Hereditary Spastic Ataxia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS07326 KLC1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18619 Klc1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25105 Klc1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Mus musculus KLC1 MGD MGI:107978
Felis catus KLC1 VGNC VGNC:104480
Rattus norvegicus KLC1 RGD RGD:621411
Others KLC1 NCBI