SFMBT1 - Scm like with four mbt domains 1 Gene
Also Known as RU1; SFMBT; hSFMBT
生物種: Homo sapiens
About SFMBT1
This gene has 8 transcripts (splice variants), 229 orthologues and 18 paralogues. Broad expression in testis (RPKM 14.1), kidney (RPKM 2.6) and 24 other tissues.
Summary
This gene shares high similarity with the Drosophila Scm (sex comb on midleg) gene. It encodes a protein which contains four malignant brain tumor repeat (mbt) domains and may be involved in antigen recognition. [provided by RefSeq, Jun 2012]
SFMBT1 Products (1)
| mRNA | Protein | Name |
|---|---|---|
| NM_016329.4 | NP_057413.2 | scm-like with four MBT domains protein 1 |
| Molecular Function GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| enables histone binding |
IDA
IDA: Inferred from direct assay
|
17599839 | GOA |
| enables protein binding |
IPI
IPI: Inferred from physical interaction
|
16189514 | GOA |
| Biological Process GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| involved in negative regulation of DNA-templated transcription |
IDA
IDA: Inferred from direct assay
|
23592795 | GOA |
| involved in negative regulation of DNA-templated transcription |
IMP
IMP: Inferred from mutant phenotype
|
17599839 | GOA |
| involved in negative regulation of muscle organ development |
IMP
IMP: Inferred from mutant phenotype
|
23349461 | GOA |
| Cellular Component GO Annotation | Evidence | 参考文献 | 由来 |
|---|---|---|---|
| located in nucleus |
IDA
IDA: Inferred from direct assay
|
17599839 | GOA |
SFMBT1 Protein Structure
MBT: mbt repeat (54 - 126)
MBT: mbt repeat (167 - 237)
MBT: mbt repeat (279 - 356)
MBT: mbt repeat (388 - 459)
SLED: SLED domain (501 - 618)
SAM_1: SAM domain (Sterile alpha motif) (795 - 857)
- 0
- 200
- 400
- 600
- 800
- 866 a.a.
| Protein Preferred Names | Protein Names | |
|---|---|---|
|
scm-like with four MBT domains protein 1 |
|
SFMBT1 Protein-protein interaction Information
|
Type
|
タンパク質名 | Protein ID | Interactor | Interactor Species | Interactor ID | Detection Method | 参考文献 |
|---|---|---|---|---|---|---|---|
|
Intra
|
SFMBT1 | Q9UHJ3 | H3-4 | Homo sapiens | Q16695 | 17599839 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | H3-4 | Homo sapiens | Q16695 | 17599839 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | ZCCHC10 | Homo sapiens | Q8TBK6 | 25416956 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | ZCCHC10 | Homo sapiens | Q8TBK6 | 25416956 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | ZCCHC10 | Homo sapiens | Q8TBK6 | 25416956 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | PHC2 | Homo sapiens | Q8IXK0 | 25416956 | |
|
Intra
|
SFMBT1 | Q9UHJ3 | PHC2 | Homo sapiens | Q8IXK0 | 16189514 |
関連疾患
| Diseases | Alias | |
|---|---|---|
| Scrotum Squamous Cell Carcinoma |
|
|
| Chromosome 20q11-Q12 Deletion Syndrome |
|
|
| Nephrolithiasis/Osteoporosis, Hypophosphatemic, 1 |
|
|
| Scrotal Carcinoma |
|
|
| Multinucleated Neurons, Anhydramnios, Renal Dysplasia, Cerebellar Hypoplasia, And Hydranencephaly |
|
|
| Poland Syndrome |
|
|
| Hydrocephalus |
|
|
| Normal Pressure Hydrocephalus |
|
|
| Communicating Hydrocephalus |
|
|
| Brachydactyly, Type A2 |
|
|
Orthologs Information
| 生物種 | Symbol | 由来 | ID |
|---|---|---|---|
| Mus musculus | SFMBT1 | MGD | MGI:1859609 |
| Felis catus | SFMBT1 | VGNC | VGNC:65061 |
| Canis familiaris | SFMBT1 | VGNC | VGNC:46076 |
| Bos taurus | SFMBT1 | VGNC | VGNC:34515 |
| Rattus norvegicus | SFMBT1 | RGD | RGD:61999 |
| Macaca mulatta | SFMBT1 | VGNC | VGNC:77279 |
| Others | SFMBT1 | NCBI |