CYB5R1 - cytochrome b5 reductase 1 Gene

Also Known as B5R1; B5R2; B5R.1; NQO3A2; humb5R2

生物種: Homo sapiens

遺伝子タイプ: protein coding
遺伝子ID: 51706

About CYB5R1

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,961,873-202,967,257 (from NCBI)

This gene has 7 transcripts (splice variants), 116 orthologues and 5 paralogues. Ubiquitous expression in skin (RPKM 57.6), heart (RPKM 53.8) and 25 other tissues.

Summary

Predicted to enable FAD binding activity. Predicted to be involved in bicarbonate transport. Located in extracellular exosome; membrane; and mitochondrion. [provided by Alliance of Genome Resources, Apr 2022]

CYB5R1 Products (1)

mRNA Protein Name
NM_016243.3 NP_057327.2 NADH-cytochrome b5 reductase 1

CYB5R1 Protein Structure

FAD_binding_6

FAD_binding_6: Oxidoreductase FAD-binding domain (50 - 155)

NAD_binding_1

NAD_binding_1: Oxidoreductase NAD-binding domain (181 - 288)

  • 0
  • 100
  • 200
  • 305 a.a.
Protein Preferred Names Protein Names

NADH-cytochrome b5 reductase 1

  • NAD(P)H:quinone oxidoreductase type 3, polypeptide A2

CYB5R1 Protein-protein interaction Information

Type
タンパク質名 Protein ID Interactor Interactor Species Interactor ID Detection Method 参考文献
Intra
CYB5R1 Q9UHQ9 UBQLN1 Homo sapiens Q9UMX0-2
Validated Y2H
25416956
Intra
CYB5R1 Q9UHQ9 UBQLN1 Homo sapiens Q9UMX0-2
Y2H Array
25416956
Intra
CYB5R1 Q9UHQ9 SLC51B Homo sapiens Q86UW2
Y2H Prey Pooling
32296183
Intra
CYB5R1 Q9UHQ9 SLC51B Homo sapiens Q86UW2
Y2H Array
32296183
Intra
CYB5R1 Q9UHQ9 HIGD1C Homo sapiens A8MV81
Y2H Prey Pooling
32296183
Intra
CYB5R1 Q9UHQ9 HIGD1C Homo sapiens A8MV81
Y2H Array
32296183
Intra
CYB5R1 Q9UHQ9 SGTA Homo sapiens O43765
Y2H Prey Pooling
32296183
Intra
CYB5R1 Q9UHQ9 SGTA Homo sapiens O43765
Y2H Array
32296183
Intra
CYB5R1 Q9UHQ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Prey Pooling
25416956
Intra
CYB5R1 Q9UHQ9 UBQLN1 Homo sapiens Q9UMX0
Y2H Array
25416956
Intra
CYB5R1 Q9UHQ9 TTC1 Homo sapiens Q99614
Y2H Array
32296183
Intra
CYB5R1 Q9UHQ9 TTC1 Homo sapiens Q99614
Y2H Prey Pooling
32296183
Intra
CYB5R1 Q9UHQ9 SGTB Homo sapiens Q96EQ0
Y2H Array
32296183
Intra
CYB5R1 Q9UHQ9 SGTB Homo sapiens Q96EQ0
Y2H Prey Pooling
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant CYB5R1 Proteins

製品番号 製品名 アクセッション番号 純度
HY-P76856 CYB5R1 Protein, Human (His) Q9UHQ9 (L29-Y305) ≥ 95%, as determined by reducing SDS-PAGE.

関連疾患

Diseases Alias
De Quervain Disease

  • Radial Styloid Tenosynovitis

  • Tenosynovitis, De Quervain'S

  • De Quervain'S Disease

  • Tenosynovitis Of Radial Styloid Process

  • Stenosans Tenosynovitis
Methemoglobinemia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
製品番号 製品名
製品効果
純度
Rare Diseases
HY-RS03419 CYB5R1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19504 Cyb5r1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25998 Cyb5r1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

生物種 Symbol 由来 ID
Macaca mulatta CYB5R1 VGNC VGNC:71398
Bos taurus CYB5R1 VGNC VGNC:97257
Canis familiaris CYB5R1 VGNC VGNC:50281
Mus musculus CYB5R1 MGD MGI:1919267
Rattus norvegicus CYB5R1 RGD RGD:1306084
Others CYB5R1 NCBI