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MAGEE1 - MAGE family member E1 Gene

Also Known as HCA1; DAMAGE

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 57692

About MAGEE1

Cytogenetic location: Xq13.3 Genomic coordinates (GRCh38): X:76,427,710-76,431,342 (from NCBI)

This gene has 1 transcript (splice variant), 295 orthologues and 37 paralogues.

Summary

This gene encodes an alpha-dystrobrevin-associated MAGE (melanoma-associated antigen) protein, which is a member of the MAGE family. The protein contains a nuclear localization signal in the N-terminus, 30 12-amino acid repeats beginning at nt 60 with the consensus sequence ASEGPSTSVLPT, and two MAGE domains in the C-terminus. It may play a signaling role in brain, muscle, and peripheral nerve. This gene is located on X chromosome in a region containing loci linked to cognitive disability. [provided by RefSeq, Mar 2010]

MAGEE1 Products (1)

mRNA	Protein	Name
NM_020932.3	NP_065983.1	melanoma-associated antigen E1

Gene Ontology

Molecular Function

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	20864041	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

MAGEE1 Protein Structure

MAGE

0
200
400
600
800
957 a.a.

Protein Preferred Names	Protein Names
melanoma-associated antigen E1	MAGE-E1 antigen

MAGEE1 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	MAGEE1	Q9HCI5	MCC	Homo sapiens	P23508	Anti Tag CoIP	33961781
Intra	MAGEE1	Q9HCI5	MCC	Homo sapiens	P23508	Y2H Array	32296183
Intra	MAGEE1	Q9HCI5	MCC	Homo sapiens	P23508	Y2H Prey Pooling	32296183
Intra	MAGEE1	Q9HCI5	EID2B	Homo sapiens	Q96D98	Anti Tag CoIP	33961781
Intra	MAGEE1	Q9HCI5	TRIM28	Homo sapiens	Q13263	TAP	20864041
Intra	MAGEE1	Q9HCI5	TRIM28	Homo sapiens	Q13263	Anti Tag CoIP	20864041

Cross: Cross-species interaction Intra: Intraspecies interaction

Diseases	Alias
Nodular Episcleritis
Melanoma	Malignant Melanoma Cutaneous Melanoma Naevocarcinoma Malignant Melanomas
Acute Contagious Conjunctivitis	Pink Eye Contagious Opthalmia Pinkeye Conjunctivitis Keratoconjunctivitis Due To Mycoplasma Conjunctivae
Acute Conjunctivitis

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07974	MAGEC2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07978	MAGEE1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Rattus norvegicus	MAGEE1	RGD	RGD:1560259
Mus musculus	MAGEE1	MGD	MGI:2148149
Others	MAGEE1	NCBI