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JAM2 - junctional adhesion molecule 2 Gene

Also Known as JAMB; CD322; IBGC8; JAM-B; VEJAM; PRO245; VE-JAM; C21orf43

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 58494

About JAM2

Cytogenetic location: 21q21.3 Genomic coordinates (GRCh38): 21:25,639,258-25,717,562 (from NCBI)

This gene has 7 transcripts (splice variants), 273 orthologues, 14 paralogues and is associated with 2 phenotypes. Broad expression in placenta (RPKM 25.9), brain (RPKM 13.2) and 20 other tissues.

Summary

This gene belongs to the immunoglobulin superfamily, and the junctional adhesion molecule (JAM) family. The protein encoded by this gene is a type I membrane protein that is localized at the tight junctions of both epithelial and endothelial cells. It acts as an adhesive ligand for interacting with a variety of immune cell types, and may play a role in lymphocyte homing to secondary lymphoid organs. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2012]

JAM2 Products (3)

mRNA	Protein	Name
NM_001270407.2	NP_001257336.1	junctional adhesion molecule B isoform 2 precursor
NM_001270408.2	NP_001257337.1	junctional adhesion molecule B isoform 3 precursor
NM_021219.4	NP_067042.1	junctional adhesion molecule B isoform 1 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables integrin binding	IDA IDA: Inferred from direct assay	12070135	GOA
enables protein binding	IPI IPI: Inferred from physical interaction	11590146	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in cell-cell adhesion	IMP IMP: Inferred from mutant phenotype	24357068	GOA
involved in cellular extravasation	IDA IDA: Inferred from direct assay	12239159	GOA
involved in hematopoietic stem cell migration to bone marrow	IMP IMP: Inferred from mutant phenotype	24357068	GOA
involved in leukocyte tethering or rolling	IDA IDA: Inferred from direct assay	19740376	GOA
involved in lymphocyte aggregation	IDA IDA: Inferred from direct assay	11823489	GOA
involved in positive regulation of lymphocyte migration	IDA IDA: Inferred from direct assay	12239159	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in cell surface	IDA IDA: Inferred from direct assay	19740376	GOA
located in cell-cell contact zone	IDA IDA: Inferred from direct assay	12239159	GOA
located in plasma membrane	IDA IDA: Inferred from direct assay	11590146	GOA
located in plasma membrane	IMP IMP: Inferred from mutant phenotype	31851307	GOA
part of protein complex involved in cell adhesion	IDA IDA: Inferred from direct assay	11590146	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JAM2 Protein Structure

V-set

I-set

0
100
200
298 a.a.

Protein Preferred Names	Protein Names
junctional adhesion molecule B	JAM-2

JAM2 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	JAM2	P57087	JAM3	Homo sapiens	Q9BX67	Protein Array	21982860

Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant JAM2 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P70385	JAM-B/CD322 Protein, Human (HEK293, His)	P57087-1 (F29-N236)	≥ 95%, as determined by reducing SDS-PAGE.

JAM2 抗体

製品番号	製品名	アプリケーション	反応性
HY-P84414	CD322 Antibody (YA4111)	WB, ICC/IF, FC, ELISA	Human
HY-P84414A	CD322 Antibody (YA4111)(PBS only)	WB, ICC/IF, FC, ELISA	Human

関連疾患

Diseases	Alias
Basal Ganglia Calcification, Idiopathic, 8, Autosomal Recessive	IBGC8
Basal Ganglia Calcification, Idiopathic, 1	Primary Familial Brain Calcification Pfbc Bspdc Bilateral Striopallidodentate Calcinosis Cerebrovascular Ferrocalcinosis IBGC1 Familial Idiopathic Basal Ganglia Calcification Idiopathic Basal Ganglia Calcification 1 Striopallidodentate Calcinosis, Bilateral Striopallidodentate Calcinosis, Autosomal Dominant, Adult-Onset Cerebral Calcification, Nonarteriosclerotic, Idiopathic, Adult-Onset Ferrocalcinosis, Cerebrovascular Fahr Disease, Familial, Formerly Basal Ganglia Calcification, Idiopathic, 3, Formerly Ibgc3, Formerly Basal Ganglia Calcification, Idiopathic, 2, Formerly Ibgc2, Formerly Fibgc Striopallidodentate Calcinosis Idiopathic Basal Ganglia Calcification Ferrocalcinosis Cerebro Vascular Autosomal Dominant Adult-Onset Striopallidodentate Calcinosis Familial Fahr Disease Ibgc2 Ibgc3 Idiopathic Basal Ganglia Calcification 2 Idiopathic Basal Ganglia Calcification 3 Non-Arteriosclerotic, Idiopathic, Adult-Onset Cerebral Calcification Basal Ganglia Calcification, Idiopathic Calcification, Basal Ganglia, Idiopathic Calcification, Basal Ganglia, Idiopathic, Type 1 Fahr'S Syndrome
Basal Ganglia Calcification	Fahr'S Syndrome Fahr'S Disease Fahr Disease
Neurogenic Bowel

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (4)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS07027	JAM2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS07028	JAM3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18768	Jam2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25256	Jam2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Mus musculus	JAM2	MGD	MGI:1933820
Rattus norvegicus	JAM2	RGD	RGD:1561692
Felis catus	JAM2	VGNC	VGNC:63001
Bos taurus	JAM2	VGNC	VGNC:50011
Canis familiaris	JAM2	VGNC	VGNC:53029
Macaca mulatta	JAM2	VGNC	VGNC:73831
Others	JAM2	NCBI