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TP53I3 - tumor protein p53 inducible protein 3 Gene

Also Known as PIG3

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9540

About TP53I3

Cytogenetic location: 2p23.3 Genomic coordinates (GRCh38): 2:24,077,433-24,084,834 (from NCBI)

This gene has 6 transcripts (splice variants), 176 orthologues and 17 paralogues. Broad expression in esophagus (RPKM 29.3), small intestine (RPKM 17.8) and 24 other tissues.

Summary

The protein encoded by this gene is similar to oxidoreductases, which are Enzymes involved in cellular responses to oxidative stresses and irradiation. This gene is induced by the tumor suppressor p53 and is thought to be involved in p53-mediated cell death. It contains a p53 consensus binding site in its promoter region and a downstream pentanucleotide microsatellite sequence. P53 has been shown to transcriptionally activate this gene by interacting with the downstream pentanucleotide microsatellite sequence. The microsatellite is polymorphic, with a varying number of pentanucleotide repeats directly correlated with the extent of transcriptional activation by p53. It has been suggested that the microsatellite polymorphism may be associated with differential susceptibility to Cancer. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]

TP53I3 Products (3)

mRNA	Protein	Name
NM_001206802.2	NP_001193731.1	quinone oxidoreductase PIG3 isoform 2
NM_004881.5	NP_004872.2	quinone oxidoreductase PIG3 isoform 1
NM_147184.4	NP_671713.1	quinone oxidoreductase PIG3 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	参考文献	由来
enables NADPH binding	IDA IDA: Inferred from direct assay	19349281	GOA
enables NADPH:quinone reductase activity	IDA IDA: Inferred from direct assay	19349281	GOA
enables protein homodimerization activity	IPI IPI: Inferred from physical interaction	19349281	GOA
enables quinone binding	IDA IDA: Inferred from direct assay	19349281	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
involved in NADP metabolic process	IDA IDA: Inferred from direct assay	19349281	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TP53I3 Protein Structure

ADH_N

ADH_zinc_N

0
100
200
300
332 a.a.

Protein Preferred Names	Protein Names
quinone oxidoreductase PIG3	NADPH:quinone reductase PIG3

Recombinant TP53I3 Proteins

製品番号	製品名	アクセッション番号	純度
HY-P74632	PIG3 Protein, Human (His)	Q53FA7 (M1-Q332)	≥ 90%, as determined by reducing SDS-PAGE.

関連疾患

Diseases	Alias
Ewing Sarcoma	Neuroepithelioma Ewing'S Tumor Primitive Neuroectodermal Tumor Ewings Sarcoma Ewing'S Sarcoma Peripheral Neuroepithelioma ES Ewings Sarcoma-Primitive Neuroectodermal Tumor Localized Peripheral Primitive Neuroectodermal Tumor Peripheral Primitive Neuroectodermal Tumor Ewing Tumor Sarcoma, Ewing'S Ewing Family Of Tumors Extraosseous Ewing Tumor Askin Tumor Ewing'S Family Localized Tumor Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing Sarcoma Localized Ewing'S Sarcoma Localized Ewing'S Sarcoma/Peripheral Primitive Neuroectodermal Tumor Localized Ewing'S Tumor Pnet Of Thoracopulmonary Region Tumor Of The Ewing Family Skeletal Ewing Sarcoma Osseous Ewing Sarcoma Ppnet Peripheral Pnet Extraskeletal Ewing Sarcoma Eoe Extraosseous Ewing Sarcoma Extraskeletal Ewing Tumor Esft Ewing Sarcoma Family Of Tumors Pne Pnet Pnet Of The Chest Wall Sarcoma, Ewing Neuroectodermal Tumors, Primitive, Peripheral Neuroectodermal Tumor, Primitive Disorder Of Eye Askin'S Tumor Extraosseous Ewings Sarcoma-Primitive Neuroepithelial Tumor Neuroepithelioma, Peripheral

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (2)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-RS14919	TP53I3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26028	Tp53i3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	TP53I3	VGNC	VGNC:47724
Rattus norvegicus	TP53I3	RGD	RGD:41235940
Macaca mulatta	TP53I3	VGNC	VGNC:79194
Bos taurus	TP53I3	VGNC	VGNC:36235
Felis catus	TP53I3	VGNC	VGNC:66464
Others	TP53I3	NCBI