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NUP155 - nucleoporin 155 Gene

Also Known as N155; ATFB15

生物種: Homo sapiens

遺伝子タイプ: protein coding

遺伝子ID: 9631

About NUP155

Cytogenetic location: 5p13.2 Genomic coordinates (GRCh38): 5:37,288,137-37,371,106 (from NCBI)

This gene has 8 transcripts (splice variants), 205 orthologues and is associated with 2 phenotypes. Broad expression in testis (RPKM 44.4), bone marrow (RPKM 5.5) and 19 other tissues.

Summary

Nucleoporins are proteins that play an important role in the assembly and functioning of the nuclear pore complex (NPC) which regulates the movement of macromolecules across the nuclear envelope (NE). The protein encoded by this gene plays a role in the fusion of NE vesicles and formation of the double membrane NE. The protein may also be involved in cardiac physiology and may be associated with the pathogenesis of Atrial Fibrillation. Alternative splicing results in multiple transcript variants of this gene. A pseudogene associated with this gene is located on chromosome 6. [provided by RefSeq, May 2013]

NUP155 Products (3)

mRNA	Protein	Name
NM_001278312.2	NP_001265241.1	nuclear pore complex protein Nup155 isoform 3
NM_004298.4	NP_004289.1	nuclear pore complex protein Nup155 isoform 2
NM_153485.3	NP_705618.1	nuclear pore complex protein Nup155 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	参考文献	由来
enables protein binding	IPI IPI: Inferred from physical interaction	25416956	GOA

Biological Process GO Annotation	Evidence	参考文献	由来
acts upstream of or within nuclear envelope organization	IDA IDA: Inferred from direct assay	19070573	GOA

Cellular Component GO Annotation	Evidence	参考文献	由来
located in nuclear envelope	IDA IDA: Inferred from direct assay	19070573	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

NUP155 Protein Structure

Nucleoporin_N

Nucleoporin_C

0
300
600
900
1200
1391 a.a.

Protein Preferred Names	Protein Names
nuclear pore complex protein Nup155	155 kDa nucleoporin

NUP155 Protein-protein interaction Information

Type	タンパク質名	Protein ID	Interactor	Interactor Species	Interactor ID	Detection Method	参考文献
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Anti Bait CoIP	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Confocal	30488537
Intra	NUP155	O75694	LMNA	Homo sapiens	P02545	Pull Down	30488537

Cross: Cross-species interaction Intra: Intraspecies interaction

NUP155 抗体

製品番号	製品名	アプリケーション	反応性
HY-P83378	NUP155 Antibody (YA3123)	WB, FC	Human
HY-P83378A	NUP155 Antibody (YA3123)(PBS only)	WB	Human

関連疾患

Diseases	Alias
Atrial Fibrillation, Familial, 15	ATFB15 Atrial Fibrillation 15 Fibrillation, Atrial, Familial, Type 15
Familial Atrial Fibrillation	Atrial Fibrillation, Familial Atfb Atrial Fibrillation Autosomal Dominant Autosomal Dominant Atrial Fibrillation Auricular Fibrillation Atrial Fibrillation Atrial Fibrillation, Familial, 1
Atrial Fibrillation	A-Fib Fibrillation, Atrial Af - [Atrial Fibrillation] Rapid Atrial Fibrillation A Fib - [Atrial Fibrillation]
Lethal Congenital Contracture Syndrome 1	LCCS1 Multiple Contracture Syndrome, Finnish Type Lccs Lethal Autosomal Recessive Syndrome Of Multiple Congenital Contractures Lethal Congenital Contracture Syndrome Type 1 Herva Disease Multiple Contracture Syndrome Finnish Type Contracture Syndrome, Lethal, Congenital, Type 1
Anterior Horn Cell Disease
Lethal Congenital Contracture Syndrome	Lccs Lethal Congenital Contracture Syndrome 1
Achalasia-Addisonianism-Alacrima Syndrome	Allgrove Syndrome Triple-A Syndrome Achalasia-Addisonianism-Alacrimia Syndrome Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder Triple A Syndrome Aaa Syndrome AAAS Glucocorticoid Deficiency With Achalasia Glucocorticoid Deficiency And Achalasia Addisonian-Achalasia Syndrome Hypoadrenalism With Achalasia Alacrima-Achalasia-Addisonianism Aaa Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima Achalasia Addisonianism Alacrimia Syndrome Achalasia Alacrima Syndrome Addisonian Achalasia Syndrome Achalasia-Addisonian Syndrome Achalasia-Alacrima Syndrome 2a Syndrome 3a Syndrome 4a Syndrome Adrenal Insufficiency-Achalasia-Alacrima Syndrome Double A Syndrome Quaternary A Syndrome Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima Allgrove'S Syndrome Adrenal Gland Hypofunction Adrenal Cortical Hypofunction
Brugada Syndrome	Sudden Unexpected Nocturnal Death Syndrome Sudden Unexplained Nocturnal Death Syndrome Bangungut Brugada Type Idiopathic Ventricular Fibrillation Pokkuri Death Syndrome Sunds Idiopathic Ventricular Fibrillation, Brugada Type Sudden Unexplained Death Dream Disease Right Bundle Branch Block, St Segment Elevation, And Sudden Death Syndrome Sudden Unexplained Death Syndrome Suds Sunds - [Sudden Unexplained Nocturnal Death Syndrome]

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

製品番号	製品名	製品効果	純度	Rare Diseases
HY-170430	HGC652	Ligand	99.53%	Unkown
HY-186250	TRIM21 ligand-1	Ligand	/	Unkown
HY-RS09686	NUP155 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

生物種	Symbol	由来	ID
Canis familiaris	NUP155	VGNC	VGNC:44046
Macaca mulatta	NUP155	VGNC	VGNC:84456
Bos taurus	NUP155	VGNC	VGNC:32352
Mus musculus	NUP155	MGD	MGI:2181182
Felis catus	NUP155	VGNC	VGNC:102275
Rattus norvegicus	NUP155	RGD	RGD:621199
Others	NUP155	NCBI