GL392
GL392 is a senolytic agent that selectively delivers the potent senolytic compound Dasatinib (HY-10181) to senescent cells. GL392 targets lipofuscin in senescent cells via the LBD domain and is linked to Dasatinib through an ester bond. Upon internalization in senescent cells, Dasatinib is released, inducing apoptosis of the senescent cells. GL392 in micelle encapsulation (mGL392) enables selective delivery to senescent cells, achieving selective senescent cell elimination in vitro and in vivo. GL392 can be used for the research of melanoma.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 分子式: C55H52ClN13O5S
- 分子量:1042.60
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
mGL392 (20-160 nM, 4 days) does not affect non-senescent B16 melanoma growth[1].
mGL392 (10 nM) selectively accumulates within senescent cells in HBEC CDC6 Tet-ON and Li-Fraumeni-p21WAF1/Cip1 Tet-ON cells[1].
mGL392 (500 nM, 4 days) induces targeted senolysis in 3D patient-derived lung organoids[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:B16 cells
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Concentration:20, 80, 160 nM
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Incubation Time:4 days
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Result:Showed no affect on non-senescent B16 melanoma growth.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6 (8-10 weeks old) subcutaneously injected with B16 melanoma cells, followed by Palbociclib-induced senescence[1]
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Dosage:0.015 mg per mouse
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Administration:i.p.; daily; 9 days
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Result:Reduced tumor volume significantly.
Induced tumor cell apoptosis.
Did not affect non-senescent B16 melanoma cell viability in vivo when senescence was absent.
Left serum markers of liver, kidney, and muscle function (including ALP, AST/ALT ratio, and CPK) within normal ranges, with no histopathological damage to vital organs observed.
化学情報
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分子量 1042.60
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分子式 C55H52ClN13O5S
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SMILES
CC1(COC(CCC(OCCN2CCN(C3=CC(NC4=NC=C(C(NC5=C(C)C=CC=C5Cl)=O)S4)=NC(C)=N3)CC2)=O)=O)NC6=CC=CC(C6=C(N1)C=C7)=C7/N=N/C(C=C8)=C9C(C=CC=C9)=C8/N=N/C%10=CC=CC=C%10
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
GL392 関連分類
HY-170851 関連分類
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