country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-125283A

Copy Link Print Information

IM176OUT05 free base

Name: IM176OUT05 free base
Brand: MedChemExpress
SKU: HY-125283A
Availability: PreOrder

(別名: 2-Me-Phen; 2-Me-Phenformin)

IM176OUT05 free base (2-Me-Phen), a biguanide, is a mitochondrial OXPHOS inhibitor. IM176OUT0 free base inhibits mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2 μM. IM176OUT05 free base activates stem cell metabolism, promotes hair regrowth and increases stemness induction and maintenance during the pluripotent stem cell generation process.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1544871-16-0
分子式: C₁₁H₁₇N₅
分子量:219.29

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (265 KB)

IM176OUT05 free base 構造式

CAS 番号: 1544871-16-0

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

IM176OUT05 (0.1-10 μM; 24 hour) free base inhibits mitochondrial function and reduces the oxygen consumption rate (OCR) as a surrogate of mitochondrial electron transport chain (ETC) activity with an IC₅₀ of 3.2 μM^[1].
IM176OUT05 (10 μM; 6 days) free base improves the acquisition and maintenance of stem cell pluripotency of mouse and human induced pluripotent stem cells (iPSCs)^[1].
IM176OUT05 (10 and 100 nM) free base facilitates the transition of glycolytic metabolism and induces of the expression of glycolysis-related genes and ETC complex enzymes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. Further protocols information, click here.

体内実験

IM176OUT05 (200 μL, 1%; apply to the depilated area, once daily) free base promotes hair regrowth in mice by stimulating the progression of the hair follicle cycle to the anagen phase and increasing the hair follicle number^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 1544871-16-0
分子量 219.29
分子式 C₁₁H₁₇N₅
SMILES

NC(NC(NCCC1=CC=CC=C1C)=N)=N
別名

2-Me-Phen; 2-Me-Phenformin
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

プロトコル

All Cell Biology

Cell Cytotoxicity Assay
Cytotoxicity assays are usually based on the assessment of cell membrane damage, which can also be indirectly detected by measuring cell viability. Detection methods include MTT assay, CKK-8 assay, LDH assay and ATP assay, etc.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (265 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Son MJ, et al. A novel and safe small molecule enhances hair follicle regeneration by facilitating metabolic reprogramming. Exp Mol Med. 2018 Dec 6;50(12):1-15.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ