JSD26
JSD26 is a selective and orally active SCoR2 (AKR1A1) inhibitor with an IC50 of 93 nM. JSD26 has 10-fold selectivity for SCoR2 versus AKR1B1. JSD26 can be used for the study acute kidney injury (AKI).
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2353515-08-7
- 分子式: C18H14N2O2
- 分子量:290.32
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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SCoR2 93 nM (IC50) |
JSD26 (120 mg/kg, i.p., once) alleviates symptoms in acute kidney injury (AKI) mice by selectively inhibiting SCoR2 and increasing S-nitrosylation of PKM2[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Healthy C57BL/6J mice[1].
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Dosage:20 mg/kg, 40 mg/kg, 80 mg/kg, 120 mg/kg
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Administration:I.p., once
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Result:At the highest dose (120 mg/kg), renal SCoR2 activity was inhibited by 80%.
Did not inhibit renal AKR1B1 activity and inhibited SCoR2 in other organs (liver, lung, heart, spleen), but showed no inhibition in brain tissue, indicating that it cannot cross the blood-brain barrier.
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Animal Model:Male C57BL/6J (9–11 weeks, 25–28 g) were induced with AKI via ischemia-reperfusion (I/R) surgery[1].
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Dosage:120 mg/kg
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Administration:I.p., once
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Result:Renal SCoR2 activity was inhibited by 80%, but SCoR2 protein expression levels remained unchanged.
Serious creatinine and BUN levels were significantly reduced, indicating improved renal function.
Histological analysis (H&E staining) showed reduced tubular damage in the JSD26 treatment group (e.g., reduced tubular dissolution and debris).
PKM2 S-nitrosylation (SNO-PKM2) levels were increased, and PKM2 activity was decreased.
化学情報
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CAS 番号 2353515-08-7
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分子量 290.32
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分子式 C18H14N2O2
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SMILES
O=C1NC(C2(C3=C(C4=CC=C(C5CC5)C=C42)C=CC=C3)N1)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
JSD26 関連分類
HY-177415 関連分類
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