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United States

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製品番号: HY-N10624

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Koshidacin B

Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2925302-01-6
分子式: C₂₈H₄₀N₄O₇
分子量:544.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (286 KB)

Koshidacin B 構造式

CAS 番号: 2925302-01-6

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- IC₅₀ & Target
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

IC₅₀ & Target

IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)^[1]

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
MRC5	CC₅₀	14.7 μM Compound: 2	Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay	[PMID: 36282784]

体外実験

Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC₅₀ values of 0.89 and 0.83 μM, respectively^[1].
Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC₅₀ value of 14.7 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Koshidacin B (30 mg/kg; i.p.; once daily for 4 d) shows vivo antiplasmodial effects^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

P. berghei N strain-infected ICR (CD1) mice^[1]
Dosage:

30 mg/kg
Administration:

Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
Result:

Suppressed 41% of malaria parasites.

化学情報

CAS 番号 2925302-01-6
分子量 544.64
分子式 C₂₈H₄₀N₄O₇
SMILES

OC[C@H](O)C(CCCCC[C@H](NC([C@H]1CCCN1C([C@@H](NC(C(C)(C)N2)=O)CC3=CC=CC=C3)=O)=O)C2=O)=O
Structure Classification
- Others
Initial Source
- Microorganisms
Pochonia boninensis
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (286 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Watanabe Y, et al. Koshidacins A and B, Antiplasmodial Cyclic Tetrapeptides from the Okinawan Fungus Pochonia boninensis FKR-0564. J Nat Prod. 2022 Oct 25. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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