country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-161360

Copy Link Print Information

LXQ-217

LXQ-217 is an oral active SHP2 inhibitor with the IC₅₀ of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2524718-79-2
分子式: C₂₄H₂₀Br₂N₂O₅
分子量:576.23

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

LXQ-217 構造式

CAS 番号: 2524718-79-2

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

LXQ-217 is an oral active SHP2 inhibitor with the IC₅₀ of 2.01 μM. LXQ-217 induces apoptosis and inhibits cell growth in vivo and in vitro^[1].

体外実験

LXQ-217 (72 h) inhibits cell growth of A549, HCT116, HepG2 and MDA-MB-231 cells with the IC₅₀ values of 2.06, 3.88, 4.53, and 5.13 μM^[1].
LXQ-217 (2.5, 5, 10 μM, 7 days) decreases the clonogenic number and formation rate of A549 cells^[1].
LXQ-217 (1.25, 2.5 μM, 24 h) inhibits the migration of A549 cells^[1].
LXQ-217 (2.5, 5, 10 μM, 3 h) increases in the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Migration Assay ^[1]

Cell Line:

A549 cells
Concentration:

1.25 and2.5 μM
Incubation Time:

72 h
Result:

Inhibited the migration of A549 cells.

Western Blot Analysis^[1]

Cell Line:

A549 cells
Concentration:

2.5, 5 and 10 μM
Incubation Time:

3 h
Result:

Increased the levels cleaved-parp (C-parp), cleaved-caspase9 (C-cas9) and cleaved-caspase3 (C-cas3) in A549 cells.

体内実験

LXQ-217 (50, 100mg/kg; Oral administration for 14 days) inhibites the growth of A549 cell xenograft model constructed based on BALB/c-nude mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

A549 cell xenograft model constructed based on BALB/c-nude mice^[1]
Dosage:

50 or 100mg/kg
Administration:

Oral administration for 14 days
Result:

Lowered tumor weight and volume of mice.

Related Protocols :

化学情報

CAS 番号 2524718-79-2
分子量 576.23
分子式 C₂₄H₂₀Br₂N₂O₅
SMILES

CCOC(C=C1)=CC=C1OC2=CC=C(C3=NN(C=O)C(C4=C(Br)C(Br)=C(O)C(O)=C4)C3)C=C2
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (271 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Sun H, et al. Small Molecule SHP2 Inhibitor LXQ-217 affects Lung Cancer Cell Proliferation in Vitro and in Vivo. Chem Biodivers. Published online February 20, 2024. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ