LY3056480
LY3056480 is a γ-secretase inhibitor. LY3056480 inhibits the Notch signaling pathway, upregulates Atoh1, promotes hair cell regeneration, and drives supporting cell transdifferentiation. LY3056480 is applicable to research related to sensorineural hearing loss.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 2064292-78-8
- 分子式: C23H28F3N3O4
- 分子量:467.48
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
LY3056480 induces the regeneration of mammalian cochlear sensory hair cells by inhibiting the Notch signaling pathway and relieving its "lateral inhibition" on inner ear supporting cells[1][2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
| NCT Number | Sponsor | Condition | Start Date |
Phase
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|---|---|---|---|---|
| NCT01329991 | Plexxikon| | 2011-05 | PHASE1 |
化学情報
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CAS 番号 2064292-78-8
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分子量 467.48
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分子式 C23H28F3N3O4
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SMILES
COC1=CC2=C([C@@H](C(C=C3N2CCC3(C)C)=O)NC([C@@H](NC(CCC(F)(F)F)=O)C)=O)C=C1
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
[1]. Schilder AGM, et al. A phase I/IIa safety and efficacy trial of intratympanic gamma-secretase inhibitor as a regenerative drug treatment for sensorineural hearing loss. Nature communications. 2024 Mar 01;15(1):1896. [Content Brief]
[2]. Samarajeewa A, et al. Therapeutic Potential of Wnt and Notch Signaling and Epigenetic Regulation in Mammalian Sensory Hair Cell Regeneration. Molecular therapy : the journal of the American Society of Gene Therapy. 2019 May 08;27(5):904-911. [Content Brief]
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
LY3056480 関連分類
HY-158012 関連分類
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