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製品番号: HY-114550

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LY339434

LY339434 is a potent and selective agonist for the hydrochloride receptor GluR5. LY339434 affects the rapid death of neurons through n-methyl-D-aspartate (NMDA) receptors.

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CAS 番号: 219566-62-8
分子式: C₁₈H₁₉NO₄
分子量:313.35

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (266 KB)

LY339434 構造式

CAS 番号: 219566-62-8

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

LY339434 is a potent and selective agonist for the hydrochloride receptor GluR5. LY339434 affects the rapid death of neurons through n-methyl-D-aspartate (NMDA) receptors^[1]^[2].

iGluR アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
HEK293	EC₅₀	>100 μM Compound: LY-339434	Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 6 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	>100 μM Compound: 32, LY-339434	Effective concentration against human GluR6 expressed in HEK293 cells Effective concentration against human GluR6 expressed in HEK293 cells	[PMID: 10821708]
HEK293	EC₅₀	0.8 μM Compound: 32, LY-339434	Effective concentration required for evoking response in HEK293 cell Effective concentration required for evoking response in HEK293 cell	[PMID: 10821708]
HEK293	EC₅₀	2.5 μM Compound: LY-339434	Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells Compound was tested for agonistic activity at Glutamate receptor 5 using HEK293 cells	[PMID: 10969973]
HEK293	EC₅₀	2.5 μM Compound: 32, LY-339434	Effective concentration against GluR5 expressed in HEK293 cells Effective concentration against GluR5 expressed in HEK293 cells	[PMID: 10821708]

体外実験

LY339434 (1-1000 μM, 24 h) inhibits cortical neuronal cell activity in a concentration-dependent manner. EC₅₀ was 11.4 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 219566-62-8
分子量 313.35
分子式 C₁₈H₁₉NO₄
SMILES

N[C@@H](C[C@@H](C/C=C/C1=CC=C2C=CC=CC2=C1)C(O)=O)C(O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (266 KB)
SDS (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Small B, et al. LY339434, a GluR5 kainate receptor agonist. Neuropharmacology. 1998 Oct-Nov;37(10-11):1261-7. [Content Brief]

[2]. Moldrich RX, et al. Excitotoxic profile of LY339434, a GluR5 agonist, in cultured murine cortical neurons. Brain Res. 2000 Apr 17;862(1-2):270-5. [Content Brief]

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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