country

Change Language

EN - English
FR - Français
DE - Deutsch
ES - Español
JA - 日本語
KO - 한국어

Country or Region:

United States

Product Name	Size / Unit Price	Qty

Total: USD 0.00 Checkout

製品番号: HY-P11862

Copy Link Print Information

Malpinin A

Name: Malpinin A
Brand: MedChemExpress
SKU: HY-P11862
Availability: PreOrder

(別名: MBJ-0173)

Malpinin A (MBJ-0173) is a dehydrohexapeptide biosurfactant with significant anthelmintic activity. Malpinin A specifically accumulates in the nematode digestive tract, thereby effectively inhibiting nematode feeding and proliferation without causing paralysis. Malpinin A can be used in studies related to plant-parasitic nematode infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2097822-76-7
分子式: C₄₄H₆₂N₁₀O₈
分子量:859.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

Malpinin A 構造式

CAS 番号: 2097822-76-7

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Malpinin A (100 μM) shows no significant cytotoxicity against SKOV-3, ACC-MESO-1, or Jurkat cells at a concentration of 100 μM^[2].
Malpinin A (10 μg) shows no antibacterial activity against Micrococcus luteus at a dose of 10 μg per disk^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Malpinin A (5.45 μg mL^-1-4× IC₅₀ concentration; exposure in culture media) potently inhibits C. elegans proliferation and feeding with an IC₅₀ of 6.35 μM, leading to reduced survival and larval hatching at higher doses^[1].
Malpinin A (100 μg mL^-1; supplementation of fungal culture media) at 100 μg mL^-1 confers nematode protection to M. indohii, significantly reducing Aphelenchus avenae propagation^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (adult hermaphrodites, stage L3−4 larvae)^[1]
Dosage:

5.45 μg mL^-1 (IC₅₀ concentration); 11.6 μM (2× IC₅₀ concentration); 4× IC₅₀ concentration
Administration:

exposure in culture media
Result:

Exhibited anthelminthic activity with an IC₅₀ of 5.45 μg mL^-1.
Killed or nearly immobilized nematodes at 4× IC₅₀, with only very few larvae hatching compared to untreated controls.
Ceased nematode feeding on bacterial food sources without immediately affecting motility.

Animal Model:

unspecified strain^[1]
Dosage:

100 μg mL^-1
Administration:

supplementation of fungal culture media
Result:

Reduced *Aphelenchus avenae* propagation drastically, with nematode numbers comparable to levels seen in cocultures with *M. alpina* (natural malpinin producer).

Animal Model:

unspecified strain (adult hermaphrodites, larvae)^[1]
Dosage:

16.92 μM (malpinin A-FAM, IC₅₀); 110 μM (malpinin A-alkyne, Raman imaging); 31 μM (malpinin A-alkyne, full anthelminthic inhibition)
Administration:

exposure in culture media
Result:

Showed high fluorescence emission originating from the entire digestive tract, including the pharynx and grinder region, in both larvae and adults via malpinin A-FAM imaging.
Distinguished malpinin A-FAM signal from autofluorescence via FLIM, confirming accumulation in the intestinal lumen.
Confirmed accumulation in the pharyngeal lumen, parts of the grinder, and the intestine via alkyne-tagged malpinin A Raman microspectroscopy.

化学情報

CAS 番号 2097822-76-7
分子量 859.03
分子式 C₄₄H₆₂N₁₀O₈
別名

MBJ-0173
配列

Ac-d{Leu-Arg-Leu}-Phe-{DHB}-d{Trp}
シーケンスの短縮

Ac-d{LRL}-F-{DHB}-d{Trp}
Structure Classification
- Peptides
Initial Source
- Microorganisms
Mortierella alpina
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Büttner H, et al. Beneficial Soil Fungus Kills Predatory Nematodes with Dehydropeptides Translocating into the Animal Gut. Journal of the American Chemical Society. 2024 Dec 18;146(50):34702-34710.

[2]. Kawahara T, et al. Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740[J]. The Journal of Antibiotics, 2017, 70(2): 226-229.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

お問い合わせ在庫あり

Other size

お問い合わせ