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製品番号: HY-P11862

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Malpinin A

Name: Malpinin A
Brand: MedChemExpress
SKU: HY-P11862
Availability: PreOrder

(別名: MBJ-0173)

Malpinin A (MBJ-0173) is a dehydrohexapeptide biosurfactant with significant anthelmintic activity. Malpinin A specifically accumulates in the nematode digestive tract, thereby effectively inhibiting nematode feeding and proliferation without causing paralysis. Malpinin A can be used in studies related to plant-parasitic nematode infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 2097822-76-7
分子式: C₄₄H₆₂N₁₀O₈
分子量:859.03

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

カスタムペプチド

Malpinin A 構造式

CAS 番号: 2097822-76-7

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

体外実験

Anti-cancerBacterial Infection

Anti-cancer

Malpinin A (100 μM) shows no significant cytotoxicity against SKOV-3, ACC-MESO-1, or Jurkat cells at a concentration of 100 μM^[2].

Bacterial Infection

Malpinin A (10 μg) shows no antibacterial activity against Micrococcus luteus at a dose of 10 μg per disk^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

体内実験

Parasitic Infection

Malpinin A (100 μg mL^-1; supplementation of fungal culture media) at 100 μg mL^-1 confers nematode protection to M. indohii, significantly reducing Aphelenchus avenae propagation^[1].
Malpinin A (5.45 μg mL^-1-4× IC₅₀ concentration; exposure in culture media) potently inhibits C. elegans proliferation and feeding with an IC₅₀ of 6.35 μM, leading to reduced survival and larval hatching at higher doses^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

unspecified strain (adult hermaphrodites, stage L3−4 larvae)^[1]
Dosage:

5.45 μg mL^-1 (IC₅₀ concentration); 11.6 μM (2× IC₅₀ concentration); 4× IC₅₀ concentration
Administration:

exposure in culture media
Result:

Exhibited anthelminthic activity with an IC₅₀ of 5.45 μg mL^-1.
Killed or nearly immobilized nematodes at 4× IC₅₀, with only very few larvae hatching compared to untreated controls.
Ceased nematode feeding on bacterial food sources without immediately affecting motility.

Animal Model:

unspecified strain^[1]
Dosage:

100 μg mL^-1
Administration:

supplementation of fungal culture media
Result:

Reduced *Aphelenchus avenae* propagation drastically, with nematode numbers comparable to levels seen in cocultures with *M. alpina* (natural malpinin producer).

Animal Model:

unspecified strain (adult hermaphrodites, larvae)^[1]
Dosage:

16.92 μM (malpinin A-FAM, IC₅₀); 110 μM (malpinin A-alkyne, Raman imaging); 31 μM (malpinin A-alkyne, full anthelminthic inhibition)
Administration:

exposure in culture media
Result:

Showed high fluorescence emission originating from the entire digestive tract, including the pharynx and grinder region, in both larvae and adults via malpinin A-FAM imaging.
Distinguished malpinin A-FAM signal from autofluorescence via FLIM, confirming accumulation in the intestinal lumen.
Confirmed accumulation in the pharyngeal lumen, parts of the grinder, and the intestine via alkyne-tagged malpinin A Raman microspectroscopy.

Related Protocols :

化学情報

CAS 番号 2097822-76-7
分子量 859.03
分子式 C₄₄H₆₂N₁₀O₈
別名

MBJ-0173
配列

Ac-d{Leu-Arg-Leu}-Phe-{DHB}-d{Trp}
シーケンスの短縮

Ac-d{LRL}-F-{DHB}-d{Trp}
Structure Classification
- Peptides
Initial Source
- Microorganism
Mortierella alpina
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Büttner H, et al. Beneficial Soil Fungus Kills Predatory Nematodes with Dehydropeptides Translocating into the Animal Gut. Journal of the American Chemical Society. 2024 Dec 18;146(50):34702-34710.

[2]. Kawahara T, et al. Novel arginine-containing peptides MBJ-0173 and MBJ-0174 from Mortierella alpina f28740[J]. The Journal of Antibiotics, 2017, 70(2): 226-229.

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