MF-592
MF-592 is an inhibitor of PGE2 (IC50=3 nM) and exhibits good oral PK properties in rats and dogs.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1064195-48-7
- 分子式: C34H33Cl2N3O6S
- 分子量:682.61
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
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Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| HEK293 | IC50 |
14 nM
Compound: 2f, MF-592
|
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting in presence of 10% human serum
|
[PMID: 21215624] |
| HEK293 | IC50 |
3 nM
Compound: 2; MF-592
|
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
Antagonist activity at human EP4 receptor expressed in HEK293 cells assessed as inhibition of PGE2-stimulated cAMP production after 1 hr by HTRF assay
|
[PMID: 26764191] |
| HEK293 | IC50 |
3 nM
Compound: 2f, MF-592
|
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
Displacement of [3H]PGE2 from human EP4 receptor expressed in HEK293 cells by scintillation counting
|
[PMID: 21215624] |
化学情報
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CAS 番号 1064195-48-7
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分子量 682.61
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分子式 C34H33Cl2N3O6S
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SMILES
O=S(C1=C(C=CC=C1Cl)Cl)(NC(NC2(CC2)CC3=CC=C(C(C)=C3)N(C4=O)CC5=C4C(OCC)=C6C=CC=CC6=C5OCC)=O)=O
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MF-592 関連分類
HY-118370 関連分類
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