製品番号: HY-119624

MOMIPP

Name: MOMIPP
Brand: MedChemExpress
SKU: HY-119624
Price: 142.00 USD
Availability: InStock
Rating: 5 (1 reviews)

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MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB).

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研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 99.00%
CAS 番号: 1363421-46-8
分子式: C₁₈H₁₆N₂O₂
分子量:292.33

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MOMIPP 構造式

CAS 番号: 1363421-46-8

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
溶剤 & 溶解度
- 体外
純度とドキュメンテーション
参考文献
Help & FAQs
関連分類
Bioz

生物活性

製品説明

MOMIPP, a macropinocytosis inducer, is a PIKfyve inhibitor. MOMIPP penetrates the blood-brain barrier (BBB)^[1]^[2].

Cellular Effect

Cell Line	Type	Value	Description	References
A-375	IC₅₀	5.02 μM Compound: 1; MOMIPP	Antiproliferative activity against human A375 cells after 48 hrs by MTS assay Antiproliferative activity against human A375 cells after 48 hrs by MTS assay	[PMID: 29878764]
A549	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human A549 cells after 48 hrs by MTS assay Antiproliferative activity against human A549 cells after 48 hrs by MTS assay	[PMID: 29878764]
BGC-823	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay Antiproliferative activity against human BGC823 cells after 48 hrs by MTS assay	[PMID: 29878764]
HCC1806	IC₅₀	>10 μM Compound: 1a; MOMIPP	Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell proliferation incubated for 24 hrs by SRB assay Antiproliferative activity against human HCC1806 cells assessed as inhibition of cell proliferation incubated for 24 hrs by SRB assay	[PMID: 37212861]
HCT-116	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay Antiproliferative activity against human HCT116 cells after 48 hrs by MTS assay	[PMID: 29878764]
HeLa	IC₅₀	1.22 μM Compound: MOMIPP	Antiproliferative activity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Antiproliferative activity against human HeLa cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38117948]
HepG2	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay Antiproliferative activity against human HepG2 cells after 48 hrs by MTS assay	[PMID: 29878764]
MCF-10A	IC₅₀	>10 μM Compound: 1; MOMIPP	Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay Cytotoxicity against human MCF10A cells assessed as reduction in cell viability after 48 hrs by MTS assay	[PMID: 29878764]
MCF7	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay Antiproliferative activity against human MCF7 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-231	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by MTS assay	[PMID: 29878764]
MDA-MB-231	IC₅₀	0.88 μM Compound: MOMIPP	Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay Antiproliferative activity against human MDA-MB-231 cells assessed as inhibition of cell viability incubated for 24 hrs by CCK8 assay	[PMID: 38117948]
MDA-MB-435S	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay Antiproliferative activity against human MDA-MB-435S cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-28	IC₅₀	8.156 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-28 cells after 48 hrs by MTS assay	[PMID: 29878764]
SK-MEL-30	IC₅₀	>10 μM Compound: 1; MOMIPP	Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay Antiproliferative activity against human SK-MEL-30 cells after 48 hrs by MTS assay	[PMID: 29878764]
U-251	GI₅₀	2.1 μM Compound: 1, MOMIPP	Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay Growth inhibition of human U251 cells preincubated for 24 hrs followed by compound-washout measured at 48 hrs by sulforhodamine assay	[PMID: 24527179]
U-251	GI₅₀	2.3 μM Compound: 1a	Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis Induction of methuosis in human U251 cells after 4 to 48 hrs by phase contrast microscopic analysis	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a	Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay Growth inhibition of human U251 cells after 48 hrs by sulforhodamine B colorimetric assay	[PMID: 27343855]
U-251	GI₅₀	2.32 μM Compound: 1a, MOMIPP	Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay Growth inhibition of human U251 cells after 24 hrs sulphorhodomine B colorimetric assay	[PMID: 25654321]
U-251	IC₅₀	1.9 μM Compound: 19, MOMIPP	Cytotoxicity against human U251 cells after 24 hrs by MTT assay Cytotoxicity against human U251 cells after 24 hrs by MTT assay	[PMID: 22335538]

体外実験

MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations^[1].
In U373 and Hs683 cell lines, 3 μM for MOMIPP induces cell vacuolization^[1].
MOMIPP (10 μM) causes early disruptions of glucose uptake and glycolytic metabolism. MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[2]

Cell Line:

U251 cells
Concentration:

10 μM
Incubation Time:

4 h or 24 h
Result:

Activated the JNK stress kinase pathway.

体内実験

MOMIPP (80 mg/kg; i.p.; once daily; for 15 consecutive days) shows moderately effective in suppressing progression of intracerebral glioblastoma xenografts^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Athymic CrTac:NCR-Foxn1 mice (female, 7-8 weeks)^[2]
Dosage:

80 mg/kg
Administration:

i.p.; once daily; for 15 consecutive days
Result:

Suppressed progression of intracerebral glioblastoma xenografts.

化学情報

CAS 番号 1363421-46-8
性状 Solid
分子量 292.33
分子式 C₁₈H₁₆N₂O₂
Color Yellow to orange
SMILES

O=C(/C=C/C1=C(NC2=C1C=C(C=C2)OC)C)C3=CC=NC=C3
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 31.25 mg/mL (106.90 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.4208 mL

17.1040 mL

34.2079 mL

5 mM

0.6842 mL

3.4208 mL

6.8416 mL

10 mM

0.3421 mL

1.7104 mL

3.4208 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Margaux Colin, et al. Dysregulation of Macropinocytosis Processes in Glioblastomas May Be Exploited to Increase Intracellular Anti-Cancer Drug Levels: The Example of Temozolomide. Cancers (Basel). 2019 Mar 22;11(3):411. [Content Brief]

[2]. Zehui Li, et al. The JNK signaling pathway plays a key role in methuosis (non-apoptotic cell death) induced by MOMIPP in glioblastoma. BMC Cancer. 2019 Jan 16;19(1):77. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	3.4208 mL	17.1040 mL	34.2079 mL	85.5198 mL
	5 mM	0.6842 mL	3.4208 mL	6.8416 mL	17.1040 mL
	10 mM	0.3421 mL	1.7104 mL	3.4208 mL	8.5520 mL
	15 mM	0.2281 mL	1.1403 mL	2.2805 mL	5.7013 mL
	20 mM	0.1710 mL	0.8552 mL	1.7104 mL	4.2760 mL
	25 mM	0.1368 mL	0.6842 mL	1.3683 mL	3.4208 mL
	30 mM	0.1140 mL	0.5701 mL	1.1403 mL	2.8507 mL
	40 mM	0.0855 mL	0.4276 mL	0.8552 mL	2.1380 mL
	50 mM	0.0684 mL	0.3421 mL	0.6842 mL	1.7104 mL
	60 mM	0.0570 mL	0.2851 mL	0.5701 mL	1.4253 mL
	80 mM	0.0428 mL	0.2138 mL	0.4276 mL	1.0690 mL
	100 mM	0.0342 mL	0.1710 mL	0.3421 mL	0.8552 mL

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MOMIPP

Vacuolin-1

PIKfyve-IN-1

EIPA

APY0201

EIPA hydrochloride

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

Bioz

MOMIPP

Vacuolin-1

PIKfyve-IN-1

EIPA

APY0201

EIPA hydrochloride

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

MOMIPP 関連分類

HY-119624 関連分類

Bioz