製品番号: HY-13301

MPC-3100

カスタマーレビュー

Based on 1 Customer Validation

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

純度: 98.4%
CAS 番号: 958025-66-6
分子式: C₂₂H₂₅BrN₆O₄S
分子量:549.44

保管条件:

Powder -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

MPC-3100 構造式

CAS 番号: 958025-66-6

容量

価格（税別）

在庫状況

数量

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

MPC-3100 is an orally bioavailable, synthetic, second-generation small-molecule inhibitor of Hsp90 with potential antineoplastic activity^[1].

HSP アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
A549	IC₅₀	0.77 μM Compound: 28g, MPC-3100	Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human A549 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
BT-474	IC₅₀	0.55 μM Compound: 28g, MPC-3100	Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human BT474 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in DU145 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
DU-145	IC₅₀	0.53 μM Compound: 28g, MPC-3100	Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human DU145 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HCT-116	IC₅₀	0.06 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay Inhibition of human HSP90 in HCT116 cells expressing Her2 gene assessed as degradation of Her2 after 4 hrs by luciferase reporter gene assay	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Akt incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in HCT116 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
HCT-116	IC₅₀	0.54 μM Compound: 28g, MPC-3100	Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HCT116 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
HT-29	IC₅₀	0.42 μM Compound: 28g, MPC-3100	Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human HT-29 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
LNCaP	IC₅₀	0.51 μM Compound: 28g, MPC-3100	Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human LNCAP cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
MV4-11	IC₅₀	0.25 μM Compound: 28g, MPC-3100	Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human MV4-11 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI/ADR-RES	IC₅₀	4.3 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-ADR-RES cells overexpressing P-gp 1 assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-H69	IC₅₀	0.15 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-H69 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
NCI-N87	IC₅₀	0.1 μM Compound: 28g, MPC-3100	Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method Inhibition of human HSP90 in NCI-N87 cells assessed as degradation of Her2 incubated for 24 hrs by Western blot method	[PMID: 22913511]
NCI-N87	IC₅₀	0.2 μM Compound: 28g, MPC-3100	Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human NCI-N87 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]
OVCAR-8	IC₅₀	0.49 μM Compound: 28g, MPC-3100	Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry Cytotoxicity against human OVCAR8 cells assessed as inhibition of tumor growth incubated for 72 hrs by luminometry	[PMID: 22913511]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 958025-66-6
性状 Solid
分子量 549.44
分子式 C₂₂H₂₅BrN₆O₄S
Color White to off-white
SMILES

NC1=C2C(N(CCC3CCN(C([C@@H](O)C)=O)CC3)C(SC4=C(Br)C=C(OCO5)C5=C4)=N2)=NC=N1
輸送条件

Room temperature in continental US; may vary elsewhere.

保管条件

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

溶剤 & 溶解度

体外:

DMSO : 5.5 mg/mL (10.01 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

1.8200 mL

9.1002 mL

18.2003 mL

5 mM

0.3640 mL

1.8200 mL

3.6401 mL

10 mM

0.1820 mL

0.9100 mL

1.8200 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (272 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Kim SH, et al. Discovery of (2S)-1-[4-(2-{6-amino-8-[(6-bromo-1,3-benzodioxol-5-yl)sulfanyl]-9H-purin-9-yl}ethyl)piperidin-1-yl]-2-hydroxypropan-1-one (MPC-3100), a purine-based Hsp90 inhibitor. J Med Chem. 2012 Sep 13;55(17):7480-501. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	1.8200 mL	9.1002 mL	18.2003 mL	45.5009 mL
	5 mM	0.3640 mL	1.8200 mL	3.6401 mL	9.1002 mL
	10 mM	0.1820 mL	0.9100 mL	1.8200 mL	4.5501 mL

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MPC-3100

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

HSP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

MPC-3100

Cell Cycle/DNA Damage Compound Library

Metabolism/Protease Compound Library

Anti-Cancer Compound Library

Clinical Compound Library

Anti-Aging Compound Library

Cytoskeleton Compound Library

Orally Active Compound Library

Heterocyclic Compound Library

Metabolic Enzyme Compound Library

Extracellular Vesicles (EVs) Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Clinical Compound Library Plus

Bioactive Compound Library

High-Throughput Bioactive Compound Library

HSP アイソフォーム固有の製品をすべて表示

生物活性

化学情報

溶剤 & 溶解度

純度とドキュメンテーション

参考文献

Help & FAQs

Complete Stock Solution Preparation Table

MPC-3100 関連分類

HY-13301 関連分類