Nelremagpran
Based on 1 Customer Validation
MRGPRX4 modulator-2 (compound 1-55) is a potent MRGPR X4 modulator, possessing antagonist activity against MRGPR X4 with an IC50 < 100 nM. MRGPRX4 modulator-2 can be used for researching autoimmune diseases such as psoriasis, multiple sclerosis, Steven Johnson’s Syndrome, and other chronic itch conditions.
商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- 純度: 99.94%
- CAS 番号: 2492595-24-9
- 分子式: C15H9ClF4O3
- 分子量:348.68
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保管条件:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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生物活性
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化学情報
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溶剤 & 溶解度
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
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GPCR/G Protein Compound Library
HY-L006
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Immunology/Inflammation Compound Library
HY-L007
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Membrane Protein-targeted Compound Library
HY-L149
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Membrane Receptor-targeted Compound Library
HY-L150
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Bioactive Compound Library Max
HY-L181
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MCE Bioactive Compound Library
HY-L001V
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Bioactive Compound Library
HY-L001
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High-Throughput Bioactive Compound Library
HY-L205
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Lactylation Compound Library
HY-L249
生物活性
IC50: < 100 nM (MRGPR X4)[1]
化学情報
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CAS 番号 2492595-24-9
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性状 Solid
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分子量 348.68
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分子式 C15H9ClF4O3
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Color White to off-white
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SMILES
O=C(O)C1=CC=CC(COC2=CC=C(C(F)(F)F)C=C2Cl)=C1F
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別名
MRGPRX4 modulator-2
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
溶剤 & 溶解度
DMSO : 50 mg/mL (143.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
純度とドキュメンテーション
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データシート (269 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Portuguese - PT (251 KB)
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取扱説明書 (2659 KB)
参考文献
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 2.8680 mL | 14.3398 mL | 28.6796 mL | 71.6990 mL |
| 5 mM | 0.5736 mL | 2.8680 mL | 5.7359 mL | 14.3398 mL | |
| 10 mM | 0.2868 mL | 1.4340 mL | 2.8680 mL | 7.1699 mL | |
| 15 mM | 0.1912 mL | 0.9560 mL | 1.9120 mL | 4.7799 mL | |
| 20 mM | 0.1434 mL | 0.7170 mL | 1.4340 mL | 3.5849 mL | |
| 25 mM | 0.1147 mL | 0.5736 mL | 1.1472 mL | 2.8680 mL | |
| 30 mM | 0.0956 mL | 0.4780 mL | 0.9560 mL | 2.3900 mL | |
| 40 mM | 0.0717 mL | 0.3585 mL | 0.7170 mL | 1.7925 mL | |
| 50 mM | 0.0574 mL | 0.2868 mL | 0.5736 mL | 1.4340 mL | |
| 60 mM | 0.0478 mL | 0.2390 mL | 0.4780 mL | 1.1950 mL | |
| 80 mM | 0.0358 mL | 0.1792 mL | 0.3585 mL | 0.8962 mL | |
| 100 mM | 0.0287 mL | 0.1434 mL | 0.2868 mL | 0.7170 mL |
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