MRK-A
MRK-A is a selective, blood-brain-barrier permeable mutant IDH1 inhibitor with an IC50 value of 5 nM. MRK-A inhibits 2-HG production. MRK-A has anti-cancer activity against brain tumors.
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研究用途以外に使用した場合、当社は一切の責任を負いかねます。
- CAS 番号: 1934301-68-4
- 分子式: C28H30N4O2
- 分子量:454.56
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保管条件:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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生物活性
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化学情報
- 純度とドキュメンテーション
- 参考文献
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Help & FAQs
生物活性
IC50: 5 nM (mutant IDH1)[1]
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| MOG-G-UVW | IC50 |
43 nM
Compound: MRK-A
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Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
Antiproliferative activity against human MOG-G-UVW cells assessed as inhibition of cell proliferation incubated for 72 hrs by cell titer-Glo assay
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[PMID: 35450359] |
化学情報
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CAS 番号 1934301-68-4
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分子量 454.56
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分子式 C28H30N4O2
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SMILES
O=C(N1CC2=CC=CN=C2NC3=CC=C(N4CCOCC4)C=C13)C5CCC6=CC=CC=C6CC5
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輸送条件
Room temperature in continental US; may vary elsewhere.
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保管条件
Please store the product under the recommended conditions in the Certificate of Analysis.
純度とドキュメンテーション
参考文献
Calculators
濃度 (開始) × 体積 (開始) = 濃度 (終了) × 体積 (終了)
MRK-A 関連分類
HY-124698 関連分類
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