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United States

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製品番号: HY-189098

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N-0159

N-0159 is a type II transmembrane serine protease (TTSP) inhibitor with anti-influenza virus activity. N-0159 exhibits a K_i of 0.06 nM against matriptase and acts through competitive and reversible inhibition of matriptase catalytic activity. N-0159 inhibits H1N1 influenza virus replication in human bronchial epithelial cells (IC₅₀ = 292 nM). N-0159 can be used for research related to influenza virus infection.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 3068741-64-7
分子式: C₃₄H₄₈N₁₂O₅S
分子量:736.89

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

N-0159 構造式

CAS 番号: 3068741-64-7

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Calu-3	IC50	292 nM	Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection. Inhibition of H1N1 virus replication in human bronchial epithelial Calu-3 cells infected with A/Puerto Rico/8/34 (PR8) at an MOI of 0.003, with viral titers evaluated 48 hrs post-infection.	37864572

体外実験

OthersViral Infection

Others

N-0159 (compound 15d) effectively inhibits recombinant human matriptase with a K_i value of 0.06 nM.
N‑0159 features homophenylalanine at the P2 position, which increases side‑chain flexibility and promotes additional π‑aromatic interactions within the matriptase active site, accounting for its higher affinity relative to IN‑2^[1].

Viral Infection

N-0159 inhibits H1N1 virus replication in Calu-3 cells with an IC₅₀ of 292 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Related Protocols :

Research Protocol for Infectious Diseases

化学情報

CAS 番号 3068741-64-7
分子量 736.89
分子式 C₃₄H₄₈N₁₂O₅S
SMILES

N=C(N)NCCC[C@H](N)C(N[C@@H](CCC(N)=O)C(N[C@@H](CCC1=CC=CC=C1)C(N[C@@H](CCCNC(N)=N)C(C2=NC3=CC=CC=C3S2)=O)=O)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Colombo É, et al. Optimization of Ketobenzothiazole-Based Type II Transmembrane Serine Protease Inhibitors to Block H1N1 Influenza Virus Replication. ChemMedChem. 2024 Jan 15;19(2):e202300458.

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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