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製品番号: HY-120569

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NC-001

NC-001 is a selective apoptosis inducer targeting renal proximal tubular cells and renal cancer cells. NC-001 inhibits tumor growth in clear cell renal cell carcinoma (CCRCC) xenograft models. NC-001 is promising for research of metastatic renal cell carcinoma.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 1237540-68-9
分子式: C₂₅H₄₁N₇O₆
分子量:535.64

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (267 KB)

NC-001 構造式

CAS 番号: 1237540-68-9

容量

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性

製品説明

Cellular Effect

Cell Line	Type	Value	Description	References
Raji	IC₅₀	0.045 μM Compound: 3, NC-001	Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of proteasome subunit beta-1i in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
Raji	IC₅₀	0.088 μM Compound: 3, NC-001	Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry Inhibition of 20s proteasome subunit beta-1c in human Raji cells using BODIPY- epoxomicin by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	>10 μM Compound: 3, NC-001	Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry Inhibition of proteasome subunit beta-2c/i in human RPMI8226 cells by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	>10 μM Compound: 3, NC-001	Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry Inhibition of proteasome subunit beta-5c/i in human RPMI8226 cells by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	0.14 μM Compound: 3, NC-001	Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry Inhibition of proteasome subunit beta-1i in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry	[PMID: 25006746]
RPMI-8226	IC₅₀	0.37 μM Compound: 3, NC-001	Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry Inhibition of 20s proteasome subunit beta-1c in human RPMI8226 cells using BODIPY-NC001 by fluorescent densitometry	[PMID: 25006746]

臨床実験

NCT Number	Sponsor	Condition	Start Date	Phase A549
NCT01329991	Plexxikon\|		2011-05	PHASE1

化学情報

CAS 番号 1237540-68-9
分子量 535.64
分子式 C₂₅H₄₁N₇O₆
SMILES

O=C([C@H]1N(C([C@H](C)NC(CN=[N+]=[N-])=O)=O)CCC1)N[C@@H](CCCC)C(N[C@@H](CC(C)C)C([C@]2(C)OC2)=O)=O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

バッチを選択:

純度: 99.98%

Assay: 99.98%

ee.: 99.98%

データシート (267 KB)
COA (2659 KB)
元素分析報告書 (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
取扱説明書 (2659 KB)

参考文献

[1]. Hedman H, et al. Abstract LB-118: NC-001 induces apoptosis and necrosis in clear cell renal cell carcinoma in vitro and in a xenograft model in vivo[J]. Cancer Research, 2012, 72(8_Supplement): LB-118-LB-118.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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分子量分子量

希釈計算機

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濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

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100 mg

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