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製品番号: HY-126473

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NE97220

NE97220 is a biochemical reagent. NE97220 induces macrophage apoptosis and reduces their viability, leading to internucleosomal DNA fragmentation. NE97220 inhibits the growth of Trypanosoma brucei rhodesiense. NE97220 is used in research on human African trypanosomiasis and immune-related studies.

商品は「研究用試薬」です。人や動物の医療用・臨床診断用・食品用の製品ではありません。
研究用途以外に使用した場合、当社は一切の責任を負いかねます。

CAS 番号: 70010-76-3
分子式: C₇H₁₂N₂O₆P₂
分子量:282.13

保管条件:

Please store the product under the recommended conditions in the Certificate of Analysis.

NE97220 構造式

CAS 番号: 70010-76-3

価格（税別）

Amount: USD 0.00

* アイテムを追加する前、数量をご選択ください

Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

生物活性
- 製品説明
- Cellular Effect
- 体外実験
- 体内実験
化学情報
純度とドキュメンテーション
参考文献
Calculators
Help & FAQs
関連分類
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生物活性

製品説明

Parasite アイソフォーム固有の製品をすべて表示 :

Cellular Effect

Cell Line	Type	Value	Description	References
J774	EC50	62 μM	Reduction of viability in murine macrophage-like J774 cells assessed by MTT assay after 48 hrs incubation. Reduction of viability in murine macrophage-like J774 cells assessed by MTT assay after 48 hrs incubation.	9797474

体外実験

NE97220 (48 h) reduces J774 cell viability with an EC₅₀ of 62 μM^[1].
NE97220 (100 μM; 48 h) causes internucleosomal DNA fragmentation in J774 macrophages^[1].
NE97220 (100 μM; 24 h) inhibits protein prenylation in J774 macrophages^[1].
NE97220 (100 μM; 48 h) induces apoptosis in J774 macrophages, resulting in 31% apoptotic cells at 100 μM^[1].
NE97220 (30 μM; 3-24 h) induces IPP/ApppI accumulation in MCF-7 cells after both continuous and pulse exposure, and is among the compounds with lower K_isom values that induce fast IPP/ApppI production^[2].
NE97220 (0.7 μM) potently inhibits the in vitro growth of Trypanosoma brucei rhodesiense, with an IC₅₀ of 0.7 μM^[3].
NE97220 inhibits GGPPSase activity with an IC₅₀ of 220.0 μM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Apoptosis Analysis^[1]

Cell Line:

J774
Concentration:

100 μM
Incubation Time:

48 h
Result:

Caused an increase in the proportion of apoptotic cells, with a percentage apoptosis of 31%.

体内実験

NE97220 (0.001 mg P/kg) inhibits bone resorption in the growing rat model with an LED of 0.001 mg P/kg^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

化学情報

CAS 番号 70010-76-3
分子量 282.13
分子式 C₇H₁₂N₂O₆P₂
SMILES

O=P(O)(C(P(O)(O)=O)NC1=NC=CC=C1C)O
輸送条件

Room temperature in continental US; may vary elsewhere.
保管条件

Please store the product under the recommended conditions in the Certificate of Analysis.

純度とドキュメンテーション

取扱説明書 (2659 KB)

参考文献

[1]. Luckman SP, et al. Heterocycle-containing bisphosphonates cause apoptosis and inhibit bone resorption by preventing protein prenylation: evidence from structure-activity relationships in J774 macrophages. Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research. 1998 Nov;13(11):1668-78.

[2]. Räikkönen J, et al. Correlation between time-dependent inhibition of human farnesyl pyrophosphate synthase and blockade of mevalonate pathway by nitrogen-containing bisphosphonates in cultured cells. Biochemical and biophysical research communications. 2011 Apr 22;407(4):663-7.

[3]. Xie A, et al. Bisphosphonates. Internet Electronic Journal of Molecular Design. 2004;3:622-50.

[4]. Ebrahimpour A, et al. Determination of solubility and calcium ion stability constants of a phosphonoalkylphosphinate (PAP) and bisphosphonates (BPs) such as EHDP, Risedronate, Alendronate, 3-pic AMBP, and 3-pic AMPMP. InMineral scale formation and inhibition 1995 (pp. 295-305). Boston, MA: Springer US.

Calculators

モル濃度計算機

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

濃度濃度

体積体積

分子量分子量

希釈計算機

濃度 _(開始) × 体積 _(開始) = 濃度 _(終了) × 体積 _(終了)

濃度 _(開始) 濃度 _(開始)

体積 _(開始) 体積 _(開始)

濃度 _(終了) 濃度 _(終了)

体積 _(終了) 体積 _(終了)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

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MOQ

Minimum order quantity

100 mg

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